Single-Cell Endoscopy for Multifunctional Live-Cell Molecular Analysis DOI Creative Commons
Hui Xue, Wang Li, Han Yao

et al.

Biosensors, Journal Year: 2025, Volume and Issue: 15(4), P. 244 - 244

Published: April 11, 2025

Molecular analyses of individual cells with high resolution, specificity, and sensitivity can not only reveal cellular heterogeneity but also provide a better understanding diseases accelerate drug discoveries. Single-cell endoscopy is an advanced live-cell technique that relies on smart endoscope allows minimally invasive probing the interiors cells. Compared other single-cell analysis techniques, has shown great promise in applications such as flexible manipulation, ultrasensitive sensing, precise intracellular delivery. In this review, we aim to map out landscape recent advances techniques by focusing both fundamental considerations significant progress over past decade. Specifically, summarize predominant endoscopes, including their fabrication characterization. Furthermore, series valuable molecular sensing events, nucleic acids, proteins, ions, etc., are introduced main emphasis how solve these issues what merits provide. Finally, briefly outline remaining challenges directions for future development techniques.

Language: Английский

The viscosity response behavior of bare nanopipettes based on ionic current rectification DOI

Yueqian Zhu,

Yuchen Wu, Xu-Fan Wang

et al.

Talanta, Journal Year: 2025, Volume and Issue: 293, P. 128111 - 128111

Published: April 10, 2025

Language: Английский

Citations

0
Single-Cell Endoscopy for Multifunctional Live-Cell Molecular Analysis DOI Creative Commons
Hui Xue, Wang Li, Han Yao

et al.

Biosensors, Journal Year: 2025, Volume and Issue: 15(4), P. 244 - 244

Published: April 11, 2025

Molecular analyses of individual cells with high resolution, specificity, and sensitivity can not only reveal cellular heterogeneity but also provide a better understanding diseases accelerate drug discoveries. Single-cell endoscopy is an advanced live-cell technique that relies on smart endoscope allows minimally invasive probing the interiors cells. Compared other single-cell analysis techniques, has shown great promise in applications such as flexible manipulation, ultrasensitive sensing, precise intracellular delivery. In this review, we aim to map out landscape recent advances techniques by focusing both fundamental considerations significant progress over past decade. Specifically, summarize predominant endoscopes, including their fabrication characterization. Furthermore, series valuable molecular sensing events, nucleic acids, proteins, ions, etc., are introduced main emphasis how solve these issues what merits provide. Finally, briefly outline remaining challenges directions for future development techniques.

Language: Английский

Citations

0