Exosomes in Regulating miRNAs for Biomarkers of Neurodegenerative Disorders

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

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Perspectives on the Application of Biosensors for the Early Detection of Oral Cancer

Sensors, Journal Year: 2025, Volume and Issue: 25(5), P. 1459 - 1459

Published: Feb. 27, 2025

Oral cancer continues to cause profound suffering and is associated with high mortality rates. Early detection techniques are crucial in enhancing patient outcomes. This review paper thoroughly evaluates the significance of biomarkers recent advancements oral detection, emphasizing cutting-edge electrochemical methods. The provides an epidemiological etiological overview, outlining its clinical importance reviewing current state art Despite considerable progress, conventional methods exhibit limitations such as invasiveness, long wait times, a lack accuracy, creating critical need for more robust technologies. emphasizes biomarkers, which considered promising cues early facilitating development innovative biosensing seeks illuminate advances precision diagnostics, along usage artificial intelligence strategies, ultimately contributing significant progress battle against cancer.

Language: Английский

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Modulating Signal Generation in Aptamer‐Based CNT‐FET Biosensors by Controlling the Functionalization Route

Advanced Sensor Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract The identification of biomarkers is key to the early detection physiological dysfunction. Nanoscale field‐effect transistors (FETs) modified with target‐specific receptors enable direct target sensing, offering enhanced sensitivity due nanoscale channel confinement. In this regard, single‐walled carbon nanotubes (SWCNTs) have emerged as strong candidates for development transistor‐based biosensors. Understanding structural parameters that affect sensing performance in such electrical platforms essential their reliable and controllable use. Here, investigated how different assembly strategies employed construction aptamer‐based SWCNT‐FET biosensors can dramatically signal generation, conductance increasing or decreasing same aptamer‐cortisol recognition event. a cortisol‐binding DNA aptamer exhibiting well‐characterized conformational behavior employed, model receptor explore influence surface functionalization on SWCNT‐based performance. Through combined optical characterization, elucidated conformation governs local electrostatic changes within Debye length, which turn modulates gating devices. This work offers insight into effective design functionalized electrostatically active molecular receptors.

Language: Английский

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Unexploited opportunities in oral disease biosensors and digital health integration

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: 576, P. 120401 - 120401

Published: May 30, 2025

Language: Английский

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Morphology-Dependent Nanoplasmonic Assay: A Powerful Signaling Platform for Multiplexed Total Antioxidant Capacity Analysis

Analytical Methods, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

This study presents a multi-colorimetric plasmonic nanostructure probe for salivary TAC evaluation. Combining colorimetric sensing with pattern recognition and regression analysis enables precise antioxidant identification quantification.

Language: Английский

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