Biopolymers, Journal Year: 2025, Volume and Issue: 116(3)
Published: May 1, 2025
ABSTRACT Inflammation is a hallmark of various pathological conditions, including cancer, cardiovascular diseases, neurodegenerative disorders, and autoimmune diseases. Reactive oxygen species (ROS) are crucial mediators in the inflammatory microenvironment, playing pivotal role both normal cellular processes disease progression. Targeting ROS overproduction inflamed tissues has emerged as promising therapeutic strategy. Polymeric nanoparticles (NPs) responsive to levels have gained substantial attention precision drug delivery systems, capable ensuring controlled, site‐specific release. This review provides comprehensive mechanistic insight into ROS‐responsive polymeric nanoparticles, examining their structural design, functionalization strategies, release mechanisms, potential for targeted therapies conditions. Furthermore, we discuss recent advancements, challenges, future directions utilizing therapeutics, highlighting transformative clinical applications.
Language: Английский