Green Synthesis of Copper Nanoparticles from the Aqueous Extract of Lonicera japonica Thunb and Evaluation of Its Catalytic Property and Cytotoxicity and Antimicrobial Activity

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(2), P. 91 - 91

Published: Jan. 9, 2025

In this study, copper nanoparticles with an average particle size of 2-4 nm were synthesized using the green extract Lonicera japonica Thunb. The catalytic activity and dye degradation efficiency Cu NPs evaluated ultraviolet spectroscopy. To confirm that can continuously remove organic dyes, study used Cu/Lj-C composite material adsorbed on cotton balls as a simulated bed to cyclic for reduction methylene blue by sodium borohydride (NaBH4). experiment showed after multiple cycles, it also quickly effectively reduce blue. evaluate toxicity NPs, experiments conducted HUVEC MC3T3-E1 cells. median lethal doses (LD50) 37.64 µg/mL 7.50 µg/mL. exhibited antibacterial efficacy against Aspergillus niger (fungus), Staphylococcus aureus (Gram-positive bacteria), Escherichia coli (Gram-negative Candida albicans (yeast).

Language: Английский

WO_3‐x@Ferrocene‐Folic Acid Composites Induce Cancer Cell Death and Activate Immunity via PTT/CDT

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

At present, tumor immune escape is a major problem in the treatment of tumors. The complex network microenvironments significantly impairs efficacy immunotherapy. This paper reports preparation and immunoantitumor activity novel multifunctional defect tungsten trioxide@ferrocene-folic acid composite (WO3-x@Fe-FA) with high Fenton reaction rate. Ferrocene modified on surface defective trioxide by covalent coupling method for first time, rate increased 10 times. WO3-x@Fe-FA induces immunogenic cell death (ICD) through powerful synergistic anti-tumor effect PTT/CDT decomposes H2O2 to produce oxygen reaction, thus down-regulating expression checkpoint PD-L1 induced hypoxia. In vitro vivo experiments proved that reverses immunosuppressive microenvironment, transforms "cold tumor" into "hot tumor", activates system. show has excellent activity, it expected be candidate drug therapy.

Language: Английский

Glucose oxidase/copper‑carbon dots/hyaluronic acid self-assembly for self-supply hydrogen peroxide in a double-enzyme cascade to enhance anti-tumor therapy

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143286 - 143286

Published: April 17, 2025

Language: Английский