Novel Biomimetic Collagen-Based Corneal Repair Material Achieved via a “Killing Two Birds with One Stone” Strategy Using Carboxymethyl-β-Cyclodextrin DOI
Kuan Cheng, Xiaohong Chen,

Yifan Yi

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Collagen, as the principal structural component of cornea, has emerged a promising biomaterial for artificial corneal owing to its excellent biocompatibility and degradability. However, mechanical properties current collagen membrane cannot match requirements materials. Inspired by hierarchical lamellar organization native stromal collagen, biomimetic collagen-based repair material was designed via "killing two birds with one stone" strategy. In this strategy, carboxymethyl-β-cyclodextrin (CM-β-CD) incorporated into serving dual functions: regulating in vitro self-assembly process molecules establishing multiple covalent cross-linking sites within network. Concurrently, controlled external shear forces were applied induce anisotropic alignment fibers, effectively replicating highly organized hierarchy characteristic tissue. The resulting exhibited 67% enhancement tensile strength (0.52 MPa) compared pure membranes. Notably, vivo keratoplasty evaluations revealed accelerated tissue regeneration, achieving complete re-epithelialization 14 days versus 28 controls. These findings establish material's potential an advanced engineering applications.

Language: Английский

Novel Biomimetic Collagen-Based Corneal Repair Material Achieved via a “Killing Two Birds with One Stone” Strategy Using Carboxymethyl-β-Cyclodextrin DOI
Kuan Cheng, Xiaohong Chen,

Yifan Yi

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Collagen, as the principal structural component of cornea, has emerged a promising biomaterial for artificial corneal owing to its excellent biocompatibility and degradability. However, mechanical properties current collagen membrane cannot match requirements materials. Inspired by hierarchical lamellar organization native stromal collagen, biomimetic collagen-based repair material was designed via "killing two birds with one stone" strategy. In this strategy, carboxymethyl-β-cyclodextrin (CM-β-CD) incorporated into serving dual functions: regulating in vitro self-assembly process molecules establishing multiple covalent cross-linking sites within network. Concurrently, controlled external shear forces were applied induce anisotropic alignment fibers, effectively replicating highly organized hierarchy characteristic tissue. The resulting exhibited 67% enhancement tensile strength (0.52 MPa) compared pure membranes. Notably, vivo keratoplasty evaluations revealed accelerated tissue regeneration, achieving complete re-epithelialization 14 days versus 28 controls. These findings establish material's potential an advanced engineering applications.

Language: Английский

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