Nickel-catalyzed cross-coupling of 2-fluorobenzofurans with arylboronic acids via aromatic C–F bond activation
Takeshi Fujita,
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Haruna Yabuki,
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Ryutaro Morioka
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et al.
Beilstein Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
21, P. 146 - 154
Published: Jan. 15, 2025
2-Fluorobenzofurans
underwent
efficient
nickel-catalyzed
coupling
with
arylboronic
acids
through
the
activation
of
aromatic
C-F
bonds.
This
method
allowed
us
to
successfully
synthesize
a
range
2-arylbenzofurans
various
substituents.
The
reaction,
which
proceeded
under
mild
conditions,
involved
β-fluorine
elimination
from
nickelacyclopropanes
formed
by
interaction
2-fluorobenzofurans
zero-valent
nickel
species.
protocol
facilitates
orthogonal
reactions
and
C-Br
bonds
acids.
Language: Английский
Controlled Defluorinative Carboxylation Cascade of Sterically Hindered CF3-Alkenes with Formate Salt via Photocatalysis
Runze Zhai,
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Haiping Yu,
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Jian‐Ping Ma
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et al.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
27(10), P. 2492 - 2497
Published: March 5, 2025
A
controlled
cleavage
of
double
C-F
bonds
in
sterically
hindered
tetrasubstituted
CF3-alkenes
using
formate
salt
has
been
achieved
through
a
photoinduced
electron
transfer
approach.
Diverse
γ-branched
multifunctionalized
gem-difluoroalkenes
and
α-fluoroacrylic
acids
are
obtained
sequentially
via
hydrodefluorination
bond
carboxylation
with
good-to-high
yields.
Precisely
controlling
the
quantity
reaction
time
is
crucial
for
obtaining
divergent
defluorinative
products.
Formate
serves
as
C1
source,
hydrogen
donor,
reducing
agent.
Language: Английский