Photoredox-Catalyzed Markovnikov Hydroamination of Alkenes with Azoles DOI

Jinhuan Nie,

Yutao Shi,

Mengran Gan

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

A visible-light induced intermolecular hydroamination of alkenes with azoles is reported, delivering pharmaceutically valuable N-benzyl in high yields excellent Markovnikov selectivity. Mechanistic studies suggest that the process initiated by energy transfer excited photocatalyst alkenes, followed single electron reduction, protonation, and subsequent oxidation to afford key alkyl carbocation intermediate. This protocol exhibits advantages broad functional group tolerance, atom economy, efficiency, mild reaction conditions.

Language: Английский

Iron-Catalyzed Oxidative Rearrangement of Cyclopropanone Hemiaminals: General Access to Pyrroloindolones from Indoles DOI
Roger Machín Rivera,

Zack R. Ferrin,

Vincent N. G. Lindsay

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(22), P. 4738 - 4743

Published: May 29, 2024

A concise synthetic approach to medicinally relevant pyrroloindolones and related fused heterocycles is reported via the diastereoselective

Language: Английский

Citations

4
Access to tetrahydrocarbazoles via a photocatalyzed cascade decarboxylation/addition/cyclization reaction DOI
Shuai Han, Zhang Chen, Yu Guo

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(23), P. 6694 - 6699

Published: Jan. 1, 2024

An efficient photocatalyzed decarboxylative coupling of indolepropionic acid NHPI esters with α,β-unsaturated carbonyl compounds has been developed, which provided structurally diverse tetrahydrocarbozles in moderate to good yields.

Language: Английский

Citations

1
Photoredox-Catalyzed Markovnikov Hydroamination of Alkenes with Azoles DOI

Jinhuan Nie,

Yutao Shi,

Mengran Gan

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

A visible-light induced intermolecular hydroamination of alkenes with azoles is reported, delivering pharmaceutically valuable N-benzyl in high yields excellent Markovnikov selectivity. Mechanistic studies suggest that the process initiated by energy transfer excited photocatalyst alkenes, followed single electron reduction, protonation, and subsequent oxidation to afford key alkyl carbocation intermediate. This protocol exhibits advantages broad functional group tolerance, atom economy, efficiency, mild reaction conditions.

Language: Английский

Citations

1