Organophotoredox Pd‐Catalyzed C–H Arylation at Room Temperature using Diaryliodonium Salts DOI Open Access

Christopher Bennett,

Nicholas McDonald, Amin A. Siddiqui

et al.

ChemPhotoChem, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract Direct functionalization of C−H bonds is the most expeditious strategy to build complexity into organic molecules. Unfortunately, Pd‐catalyzed arylation strategies require high temperatures and/or stoichiometric oxidants. The discovery metallaphotoredox in 2011 forged a new approach achieve metal catalyzed at room temperature. Since this discovery, reports still use explosive diazonium salts as aryl radical precursors. Alternatively, single report uses bench‐stable diaryliodonium salts, albeit with an Ir‐based photocatalyst. In study, we develop organophotoredox manifold that enables numerous N ‐aryl amide substrates. results present are expected revitalize temperature arylations wide‐ranging classes bonds.

Language: Английский

Organophotoredox Pd‐Catalyzed C–H Arylation at Room Temperature using Diaryliodonium Salts DOI Open Access

Christopher Bennett,

Nicholas McDonald, Amin A. Siddiqui

et al.

ChemPhotoChem, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract Direct functionalization of C−H bonds is the most expeditious strategy to build complexity into organic molecules. Unfortunately, Pd‐catalyzed arylation strategies require high temperatures and/or stoichiometric oxidants. The discovery metallaphotoredox in 2011 forged a new approach achieve metal catalyzed at room temperature. Since this discovery, reports still use explosive diazonium salts as aryl radical precursors. Alternatively, single report uses bench‐stable diaryliodonium salts, albeit with an Ir‐based photocatalyst. In study, we develop organophotoredox manifold that enables numerous N ‐aryl amide substrates. results present are expected revitalize temperature arylations wide‐ranging classes bonds.

Language: Английский

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