Electrochemical Oxidation of Benzyl Alcohols via Hydrogen Atom Transfer Mediated by 2,2,2-Trifluoroethanol
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 29, 2025
We
report
a
novel
electrochemical
oxidation
of
benzyl
alcohols.
found
that
trifluoroethanol
plays
role
as
hydrogen
atom
transfer
(HAT)
mediator,
enabling
the
electron-deficient
substrates
are
difficult
to
directly
oxidize
on
electrode
surfaces.
Density
functional
theory
calculations,
cyclic
voltammetry
measurements,
and
constant
potential
electrolysis
studies
supported
proposed
HAT
mechanism.
Moreover,
obtained
carbonyl
compounds
could
be
functionalized
in
an
one-pot
manner,
further
highlighting
their
synthetic
utility.
Language: Английский
Photoredox Radical Truce–Smiles Rearrangement of N-Sulfinyl Acrylamides with Bromodifluoroacetamides
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 18, 2024
We
herein
report
a
photochemical
Truce–Smiles
rearrangement
reaction
of
N-sulfinyl
acrylamides
with
bromodifluoroacetamides
resulting
in
the
synthesis
series
aryl
difluoroglutaramides
moderate
to
good
yields.
The
asymmetric
using
chiral
sulfinamides
produced
quaternary
carbon-centered
glutaramide
products
modest
enantioselectivity.
This
protocol
effectively
complements
previous
methods
involving
N-sulfonyl
acrylamides.
Language: Английский