Recent Advances in Catalytic Asymmetric Ketone Allylations and Their Applications
Lie Wang,
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Ruoshi Jin,
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Yiyuan Peng
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et al.
ACS Catalysis,
Journal Year:
2025,
Volume and Issue:
15(3), P. 1487 - 1513
Published: Jan. 9, 2025
Due
to
the
wide
applications
of
resulting
chiral
tertiary
homoallylic
alcohols
in
organic
synthesis,
catalytic
asymmetric
ketone
allylations
have
attracted
continuous
attention
from
synthetic
chemists.
Despite
inherent
difficulty
enantiofacial
differentiation
and
low
reactivity
ketones,
past
two
decades
witnessed
rapid
progress
allylation
ketones.
Many
efficient
methods
been
reported,
with
discovery
unprecedented
catalysts
reagents.
The
current
Review
aims
give
a
summary
achievements
this
area
2011
date
is
divided
into
six
parts
according
reagents
that
were
applied.
Special
paid
scope
application
each
method
brief
introduction
corresponding
mechanisms.
Language: Английский
Assembly of (E)‐γ‐Lactones Fused Five‐ or Six‐Membered Ring via Palladium‐Catalyzed Cascade Annulation Reaction
Jianxiao Li,
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Yanan Niu,
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Dan He
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et al.
Chemistry - An Asian Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 20, 2025
Abstract
A
palladium‐catalyzed
divergent
cascade
annulation
reaction
of
unactivated
cycloalkenes
with
alkynoic
acids
under
aerobic
conditions
is
accomplished.
This
catalytic
protocol
provides
an
efficient
and
economical
strategy
to
accommodate
a
broad
scope
(E)‐
γ
‐lactones
fused
five‐
or
six‐membered
ring
motifs
good
regioselectivities
yields
(
57
examples,
up
94
%
yield
E/Z
98
:
2
).
More
importantly,
the
developed
applicable
wide
array
cycloalkenes,
including
cyclopentene,
cyclohexa‐1,3‐diene,
cyclohexa‐1,4‐diene,
cyclohepta‐1,3‐diene
conjugated
1,3‐diene.
Language: Английский
Medicinally Significant Enantiopure Compounds from Garcinia Acid Isolated from Garcinia gummi-gutta
Simimole Haleema,
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Chithra Gopinath,
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Zabeera Kallingathodi
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et al.
Symmetry,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1331 - 1331
Published: Oct. 9, 2024
Garcinia
gummi-gutta,
commonly
known
as
cambogia
(syn.),
is
a
popular
traditional
herbal
medicine
for
its
role
in
treating
obesity,
and
has
been
incorporated
into
several
nutraceuticals
globally
this
purpose.
The
fruit
rind
also
used
food
preservative
condiment
because
of
high
content
hydroxycitric
acid,
which
imparts
sharp,
sour
flavour.
This
review
highlights
the
major
bioactive
compounds
present
tree
with
particular
emphasis
on
(2S,
3S)-tetrahydro-3-hydroxy-5-oxo-2,3-furan
dicarboxylic
referred
to
garcinia
acid.
acid
can
be
isolated
large
amounts
through
simple
procedure.
Additionally,
it
explores
synthetic
transformations
biologically
potent
functionally
useful
enantiopure
compounds,
relatively
under-documented
area
literature.
six-carbon
skeleton,
γ-butyrolactone
moiety,
two
chiral
centres
bearing
chemically
amenable
functional
groups,
offers
versatile
framework
chiron
construction
diverse
molecules
both
natural
origin.
synthesis
3-substituted
3,4-disubstituted
pyrrolidine-2,5-diones,
analogues
Quararibea
metabolite—a
enolic-γ-lactone;
concave
bislactone
skeletons
fungal
metabolites
(+)-avenaciolide
(−)-canadensolide;
structural
furo[2,3-b]furanol
part
anti-HIV
drug
Darunavir;
(−)-tetrahydropyrrolo[2,1-a]isoquinolinones,
an
analogue
(−)-crispine
A;
(−)-hexahydroindolizino[8,7-b]indolones,
naturally
occurring
(−)-harmicine;
furo[2,3-b]pyrroles
are
presented
here.
Language: Английский