Recent Advances in Catalytic Asymmetric Ketone Allylations and Their Applications

ACS Catalysis, Journal Year: 2025, Volume and Issue: 15(3), P. 1487 - 1513

Published: Jan. 9, 2025

Due to the wide applications of resulting chiral tertiary homoallylic alcohols in organic synthesis, catalytic asymmetric ketone allylations have attracted continuous attention from synthetic chemists. Despite inherent difficulty enantiofacial differentiation and low reactivity ketones, past two decades witnessed rapid progress allylation ketones. Many efficient methods been reported, with discovery unprecedented catalysts reagents. The current Review aims give a summary achievements this area 2011 date is divided into six parts according reagents that were applied. Special paid scope application each method brief introduction corresponding mechanisms.

Language: Английский

Assembly of (E)‐γ‐Lactones Fused Five‐ or Six‐Membered Ring via Palladium‐Catalyzed Cascade Annulation Reaction

Chemistry - An Asian Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract A palladium‐catalyzed divergent cascade annulation reaction of unactivated cycloalkenes with alkynoic acids under aerobic conditions is accomplished. This catalytic protocol provides an efficient and economical strategy to accommodate a broad scope (E)‐ γ ‐lactones fused five‐ or six‐membered ring motifs good regioselectivities yields ( 57 examples, up 94 % yield E/Z 98 : 2 ). More importantly, the developed applicable wide array cycloalkenes, including cyclopentene, cyclohexa‐1,3‐diene, cyclohexa‐1,4‐diene, cyclohepta‐1,3‐diene conjugated 1,3‐diene.

Language: Английский

Medicinally Significant Enantiopure Compounds from Garcinia Acid Isolated from Garcinia gummi-gutta

Symmetry, Journal Year: 2024, Volume and Issue: 16(10), P. 1331 - 1331

Published: Oct. 9, 2024

Garcinia gummi-gutta, commonly known as cambogia (syn.), is a popular traditional herbal medicine for its role in treating obesity, and has been incorporated into several nutraceuticals globally this purpose. The fruit rind also used food preservative condiment because of high content hydroxycitric acid, which imparts sharp, sour flavour. This review highlights the major bioactive compounds present tree with particular emphasis on (2S, 3S)-tetrahydro-3-hydroxy-5-oxo-2,3-furan dicarboxylic referred to garcinia acid. acid can be isolated large amounts through simple procedure. Additionally, it explores synthetic transformations biologically potent functionally useful enantiopure compounds, relatively under-documented area literature. six-carbon skeleton, γ-butyrolactone moiety, two chiral centres bearing chemically amenable functional groups, offers versatile framework chiron construction diverse molecules both natural origin. synthesis 3-substituted 3,4-disubstituted pyrrolidine-2,5-diones, analogues Quararibea metabolite—a enolic-γ-lactone; concave bislactone skeletons fungal metabolites (+)-avenaciolide (−)-canadensolide; structural furo[2,3-b]furanol part anti-HIV drug Darunavir; (−)-tetrahydropyrrolo[2,1-a]isoquinolinones, an analogue (−)-crispine A; (−)-hexahydroindolizino[8,7-b]indolones, naturally occurring (−)-harmicine; furo[2,3-b]pyrroles are presented here.

Language: Английский