Tau protein aggregation: A therapeutic target for neurodegenerative diseases DOI

Aryan Duggal,

Drishti Mahindru,

Kirti Baghel

et al.

Advances in protein chemistry and structural biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Influence of LNA modifications on the activity of the 10–23 DNAzyme DOI Creative Commons

Marcelo Muñoz-González,

Rodrigo Aguilar, Adrián A. Moreno

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(17), P. 13031 - 13040

Published: Jan. 1, 2025

LNA modifications enhance 10–23 DNAzyme activity and stability, cleaving a region of the MALAT1 RNA in vitro cells.

Language: Английский

Citations

0
Self-protective DNAzyme-based dual-responsive three-way Y-probe for simultaneous determination of multiple pathogenic bacteria DOI
Bowen Li, Xinru Ren, Yilin Xiao

et al.

Analytical and Bioanalytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

Citations

0
Functional Nucleic Acid Nanostructures for Mitochondrial Targeting: The Basis of Customized Treatment Strategies DOI Creative Commons
Wanchong He,

Siyu Dong,

Qinghua Zeng

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1025 - 1025

Published: Feb. 24, 2025

Mitochondria, as vital organelles, play a central role in subcellular research and biomedical innovation. Although functional nucleic acid (FNA) nanostructures have witnessed remarkable progress across numerous biological applications, strategies specifically tailored to target mitochondria for molecular imaging therapeutic interventions remain scarce. This review delves into the latest advancements leveraging FNA mitochondria-specific cancer therapy. Initially, we explore creation of FNA-based biosensors localized mitochondria, enabling real-time detection visualization critical molecules essential mitochondrial function. Subsequently, examine developments aimed at mitochondrial-targeted treatments, including modular nanodevices precise delivery agents programmable disrupting processes. Emphasis is placed on elucidating chemical principles underlying design mitochondrial-specific nanotechnology diverse uses. Lastly, address unresolved challenges outline prospective directions, with goal advancing field encouraging sophisticated tools both academic inquiry clinical applications centered mitochondria.

Language: Английский

Citations

0
Recent advances in DNA nanotechnology for cancer detection and therapy: A review DOI

Donya Esmaeilpour,

Matineh Ghomi, Ehsan Nazarzadeh Zare‬

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142136 - 142136

Published: March 1, 2025

Language: Английский

Citations

0
Signal Transduction Strategies for DNAzyme-Based Sensing and Imaging of Metal Ions in Cells and in Vivo DOI Creative Commons
Whitney Lewis, A. P. Farrell, Subhashree Pradhan

et al.

Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Language: Английский

Citations

0
Tau protein aggregation: A therapeutic target for neurodegenerative diseases DOI

Aryan Duggal,

Drishti Mahindru,

Kirti Baghel

et al.

Advances in protein chemistry and structural biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0