N-Iodosuccinimide-Promoted Synthesis of Indolo[3,2-c]quinolizines via Cascade Intramolecular C–N Bond Formation/Aromatization with 3-(1H-Indol-3-yl)-2-(pyridin-2-yl)propanoates

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

An NIS-promoted cascade of intramolecular C-N bond formation/aromatization with 3-(1H-indol-3-yl)-2-(pyridin-2-yl)propanoates is described for synthesizing a polycyclic indole skeleton, indolo[3,2-c]quinolizine, as well 1,9-dihydropyrazolo[4',3':5,6]pyrido[2,3-b]indole. The advantages this protocol include accessible starting materials, mild conditions, simple operation, and good yields. Indolo[3,2-c]quinolizines exhibited fluorescence properties effective staining live cells, targeting lysosomes mitochondria. Additionally, the products showed significant antiproliferative activity against tumor cells in MTT assay.

Language: Английский

Four-component modular synthesis of sulfonylated indolo[2,1-a]isoquinolines via SO2 insertion/Smiles rearrangement radical relay strategy

Green Synthesis and Catalysis, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский