Ball-mill-assisted mechanochemical approaches for heterocyclic compound synthesis (2015–2024) DOI

Mohd Rashid,

Shivani Kasana,

Vaibhav Nigam

et al.

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

Thermodynamic and Structural Characterization of a Mechanochemically Synthesized Pyrazinamide–Acetylsalicylic–Acid Eutectic Mixture DOI Creative Commons
Luís Henrique Silva Queiroz, Mateus R. Lage, Clenilton Costa dos Santos

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 211 - 211

Published: Feb. 5, 2025

Background/Objectives: This study aims to develop a sustainable and environmentally friendly drug delivery system by synthesizing novel drug–drug eutectic mixture (DDEM) of acetylsalicylic acid (ASA) pyrazinamide (PZA) using green efficient mechanochemical approach. Methods: The DDEM was characterized various techniques, including differential scanning calorimetry (DSC), thermogravimetry thermal analysis (TG-DTA), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy. Binary phase diagrams Tammann’s triangle determined the point. Density functional theory (DFT) calculations were performed on starting compounds. new evaluated for aqueous solubility, dissolution, hygroscopicity. Results: A V-shaped binary diagram indicated formation with 2:1 molar ratio ASA PZA. positive mixing enthalpy suggested quasi-eutectic structure. solubility PZA increased 61.5% 85.8%, respectively, in compared pure drugs. Conclusions: These findings highlight potential DDEMs enhance properties delivery. synergistic interaction between may further improve therapeutic efficacy, warranting investigation.

Language: Английский

Citations

1
Shaken not stirred: procedures in mechanochemical syntheses and how to define them DOI Creative Commons
James D. Batteas, Tomislav Friščić

RSC Mechanochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

James Batteas and Tomislav Friščić outline the need for well-defined reporting methodologies in mechanochemistry.

Language: Английский

Citations

0
Mechanochemical Enantiospecific Syntheses of Sulfonimidate Esters and Sulfonimidamides by Various S(VI) Exchange Reactions DOI Creative Commons

Shubhangi Tripathi,

Sidharam P. Pujari,

Marjorie Romkes

et al.

ChemistryEurope, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Mechanochemical S(VI) exchange reactions are developed on chiral S(VI)–F and S(VI)–Cl centers that fast, solvent–free, high–yielding, enantiospecific. This approach is used to synthesize a range of sulfonimidate esters sulfonimidamides from sulfonimidoyl fluorides chlorides under mild reaction conditions. The broad scope this method demonstrated by its successful reactivity with phenols both primary secondary anilines. Furthermore, substitution in 4–nitrophenol‐derived species substituted (SuPhenEx) successfully achieved. faster, greener, reduces the need for formation fluorinated species, while retaining many advantages SuFEx related reactions.

Language: Английский

Citations

0
Ball-mill-assisted mechanochemical approaches for heterocyclic compound synthesis (2015–2024) DOI

Mohd Rashid,

Shivani Kasana,

Vaibhav Nigam

et al.

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

Citations

0