Recent advance development in pillar[5]arene-based nanomaterials for cancer therapy

Chemical Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In this review, we summarize five different types of pillar[5]arene-based nanomaterials and their applications in chemotherapy, photodynamic therapy, photothermal multimodal synergistic therapy for tumors.

Language: Английский

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A hyaluronic acid modified copper-based metal-organic framework overcomes multidrug resistance via two-way redox dyshomeostasis under hypoxia

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140148 - 140148

Published: Jan. 1, 2025

Language: Английский

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Editorial: Supramolecular cancer therapeutic biomaterials-volume II

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: March 5, 2025

briefly introduce the research work of this new topic.Hepatocellular carcinoma (HCC) has fourth highest death rate among all cancer types worldwide. Programmed cell (PCD) is a key biological mechanism for controlling progression, tumor expansion and metastasis. In addition, Tumor microenvironment (TME) critical in influencing Overall survival (OS) immune response to immunotherapy interventions. From multi-omics perspective, combination PCD TME helps predict patients with liver cancer. Liu et al. analyzed changes classifiers used classify into two subgroups (high PVD-low low PVD-high TME). Next, they compared somatic mutation (TMB), response, functional annotation between groups. Finally, Western blot (WB) was performed. Immunohistochemistry (IHC) assessed on Human Protein Map (HPA). PCD-TME classifier, 23 PCD-related genes three were identified. Using model, patients' prognosis treatment can be accurately predicted. The results study provide tool clinical management hepatocellular help develop accurate strategies these (Liu 2024).Fluorescence imaging near-infrared-II region advantages centimeter-scale tissue penetration micron-scale spatial resolution, which sparked interest visualizing lymphatic system. Jin prepared HA@ICG nanoparticles based NIR-II fluorescence characteristics ICG, inhibited π-π stacking ICG molecules, had an ideal particle size surface modification, good duration could assess local microcirculation. vitro vivo studies demonstrated that it excellent photostability, biosafety visualization ability system, expected clinic (Zhang 2024). However, further needed validation disease models deep-seated tissues.In paper, Prof. Wang coworkers proposed metal-organic framework (MOF)-based nano-platform mitochondrial-targeted CO gas therapy drug therapy. They designed thiol-functionalized MOF (UiO-66-SH) combined resveratrol (RES) form UiO@FeCO@RES nano-platform. platform capable triggering decomposition by ATP within cells, releasing RES generating gas, achieving synergistic anti-cancer effects inhibiting ATPase disrupting mitochondrial function. Experimental show effectively target mitochondria release ROS, significantly enhancing killing effect cells (Wang 2025). This strategy combining provides ideas treatment.In mini-review Fukuhara focuses application progress dynamic stimuli-responsive supramolecular chemosensors detection, particular attention external stimulus solution-state hydrostatic pressure its role systems. Focusing mechanical force pressure, found HeLa regulates influx Ca²⁺ through piezo ion channel, mainly affecting intracellular pathway, have restore original state channel. These findings suggest importance systems (Matsumoto different pressure-responsive peptide scaffolds development reagents promote future mechanobiology.In summary, we highly value endeavors, understandings, outlooks every contributor domain therapeutic biomaterials. We sincerely hope issue offer perspective applying chemistry address biomedical issues encourage -depth field.

Language: Английский

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A pillar[5]arene-based supramolecular fluorescent probe for selective GSH detection and GSH-activated mitochondrial targeting cell imaging

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142272 - 142272

Published: April 1, 2025

Language: Английский

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