Spherical Amides with C3 Symmetry: Improved Synthetic Approach and Structural/Optical Analysis DOI Creative Commons

Daiki Koike,

Hyuma Masu, Hiroshi Uno

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1074 - 1074

Published: Feb. 26, 2025

A spherical amide with C3 symmetry was synthesized by a one-step cyclization reaction using triphenylphosphine and hexachloroethane as coupling reagents. This method enabled synthesis of N-benzyl N-allyl derivatives, which could not be obtained the previously reported method. The optical resolution each compound measured, their electronic circular dichroism spectra revealed that they were mirror images. high structural resulted in higher Δε (molar absorption difference against right or left polarization: εL - εR value compared to another isomer previously. absolute structure enantiopure crystal derivative determined Flack parameter X-ray crystallographic analysis.

Language: Английский

Spherical Amides with C3 Symmetry: Improved Synthetic Approach and Structural/Optical Analysis DOI Creative Commons

Daiki Koike,

Hyuma Masu, Hiroshi Uno

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1074 - 1074

Published: Feb. 26, 2025

A spherical amide with C3 symmetry was synthesized by a one-step cyclization reaction using triphenylphosphine and hexachloroethane as coupling reagents. This method enabled synthesis of N-benzyl N-allyl derivatives, which could not be obtained the previously reported method. The optical resolution each compound measured, their electronic circular dichroism spectra revealed that they were mirror images. high structural resulted in higher Δε (molar absorption difference against right or left polarization: εL - εR value compared to another isomer previously. absolute structure enantiopure crystal derivative determined Flack parameter X-ray crystallographic analysis.

Language: Английский

Citations

0