Assessing the Environmental Risks of Sulfonylurea Pollutants: Insights into the Risk Priority and Structure-Toxicity Relationships Explorations DOI

Zhi-Cong He,

Tao Zhang,

Xin-Fang Lu

et al.

Published: Jan. 1, 2024

Language: Английский

Spectroscopic investigation of the ultrasound impacts on the molecular structures of blood proteins DOI Creative Commons
Aysh Y. Madkhli, Waad A. Al‐Otaibi, Sahar M. AlMotwaa

et al.

Chemical Physics Impact, Journal Year: 2025, Volume and Issue: 10, P. 100844 - 100844

Published: Jan. 31, 2025

Language: Английский

Citations

0
Sialylation Shields Glycoproteins from Oxidative Stress: Mechanistic Insights into Sialic Acid Oxidation and Structural Stability DOI
Yamei Wang,

D. P. Jin,

Liping Ren

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Sialylation, a crucial yet labile protein modification, is increasingly recognized for its role in modulating structure, function, and stability. While the impact of oxidative stress on integrity well-established, protective sialylation against such damage remains poorly understood. This study employs microscale low-temperature plasma device to generate controlled, deep radical oxidation environment mimicking cellular stress. By subjecting free sialic acids (Neu5Ac Neu5Gc) time-resolved exposure, high-resolution mass spectrometry, high-fidelity density functional theory calculations, we establish an unprecedented pathway, revealing unique stepwise side chain prior ring opening. Comprehensive maps comprising over 100 intermediates provide molecular basis higher propensity Neu5Gc Neu5Ac resisting oxidation. Further, using human transferrin as model glycoprotein, demonstrate unfolding. Through combination site mapping, enzymatic treatments, all-ion unfolding ion mobility-mass identify specific patterns structural motifs that are maintaining stability under Our findings insights into intricate interplay between stress, highlighting importance stabilizing conformations various stresses.

Language: Английский

Citations

0
Insights on the interactions between functionalized metal-polyphenol nanocarriers and human serum albumin via spectroscopic analysis DOI

Ning Hao,

Ruihong Lv,

Shanshan Gao

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106757 - 106757

Published: March 1, 2025

Language: Английский

Citations

0
Ratio of red blood cell distribution width to albumin level and risk of mortality in sarcopenic obesity DOI Creative Commons

Xiong-Bin Ma,

Yan-Lin Lv,

Qian Lin

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 13, 2024

The aim of this study was to investigate the relationship between red blood cell distribution width and albumin ratio (RAR) levels mortality in adult patients with sarcopenic obesity United States. included 1,361 from National Health Nutrition Examination Survey (1999–2006). X-tile used determine optimal subgroup thresholds for RAR values, propensity score matching (PSM) employed reduce baseline bias. Cox regression analysis, Kaplan-Meier survival curves, restricted cubic spline analysis were utilized assess all-cause cardiovascular mortality. Subgroup Subpopulation Treatment Effect Pattern Plot advantages across different subgroups. Time-dependent ROC evaluate accuracy level predicting outcomes at time points. Post-PSM multifactorial analyses revealed that a significant independent predictor (HR 1.487, 95% CI: 1.259–1.756) an risk factor 1.260–1.758) obesity. advantage consistent Restricted indicated approximate S-shaped association curves demonstrate areas under 1-year, 3-year, 5-year, 10-year are 0.79, 0.66, 0.64, 0.63, respectively. curve 0.80, 0.70, 0.61, Moreover, comparison model lacking covariates, AUC values joint exhibited heightened various Therefore, We demonstrated is prognostic American population obesity, it reasonable consider as simple effective prediction tool.

Language: Английский

Citations

1
Prognostic prediction of oxidative stress related hematological biomarkers in locally advanced cervical cancer patients undergoing chemoradiotherapy DOI
Gang Wu,

Mengxuan Gu,

Jiahao Zhu

et al.

Biomarkers, Journal Year: 2024, Volume and Issue: 29(5), P. 255 - 264

Published: May 20, 2024

This investigation aimed to develop and validate a novel oxidative stress score for prognostic prediction in locally advanced cervical cancer (LACC) patients receiving chemoradiotherapy.

Language: Английский

Citations

0
Assessing the Environmental Risks of Sulfonylurea Pollutants: Insights into the Risk Priority Ranking and Structure-Toxicity Relationships Explorations DOI

Wei Peng,

Zhi-Cong He,

Tao Zhang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Assessing the Environmental Risks of Sulfonylurea Pollutants: Insights into the Risk Priority and Structure-Toxicity Relationships Explorations DOI

Zhi-Cong He,

Tao Zhang,

Xin-Fang Lu

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0