The Transformative Role of Nanoenzymes in the Diagnosis, Targeted Treatment, and Prognosis of Ovarian Cancer. A comprehensive review DOI Creative Commons
Ahmed Imran,

Aqsa Gulzar,

Muhammad Rehman Gulzar

et al.

Developmental medico-life-sciences, Journal Year: 2024, Volume and Issue: 1(10), P. 4 - 22

Published: Dec. 13, 2024

Ovarian cancer is one of the most aggressive and deadly gynaecological malignancies remains frequently diagnosed at advanced stages because its asymptomatic progression inherent limitations current diagnostic tests. Nanoenzymes (a class nanotechnology-based artificial enzymes) have great promise in addressing these challenges. greatly improve sensitivity specificity biosensors including optical electrochemical systems, with real-time high-precision detection key biomarkers such as CA-125, HE4, mesothelin. The high accuracy biosensors, fluorescence surface plasmon resonance (SPR) based technologies, for early-stage diagnosis, cost-effective, portable, ultra-low limits make them attractive alternatives. Nanoenzyme-based drug delivery systems like liposomes, polymeric micelles, Nanocapsules therapeutic outcomes by allowing targeted transport to tumor tissues, reducing systemic toxicity, overcoming resistance treatment. PEGylated liposomal doxorubicin (Doxil), a formulation, has been shown enhanced efficacy platinum-resistant ovarian cancer, reduced adverse effects. Further theranostic applications metallic nanoparticles gold iron oxide can be realized using therapy imaging. These advancements come their challenges, however, biological barriers, scalability before clinical translation. Interdisciplinary research, validation, creation regulatory frameworks safety are needed future progress. offer revolutionize diagnosis treatment potential facilitate early detection, precision, patient outcome while filling huge gaps approaches.

Language: Английский

Advancements in Nanomedicine for the Diagnosis and Treatment of Kidney Stones DOI Creative Commons
Wang Yong-qi,

Junyi Yang,

Yirixiatijiang Amier

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1401 - 1423

Published: Feb. 1, 2025

Abstract: Kidney stones constitute a common condition impacting the urinary system. In clinical diagnosis and management, traditional surgical interventions pharmacological treatments are primarily utilized; however, these methods possess inherent limitations. Presently, field of nanomedicine is undergoing significant advancements. The application nanomaterials in biosensors enables accurate assessment ion composition. Furthermore, contrast agents developed from materials can improve signal-to-noise ratio enhance image clarity. By mitigating oxidative stress-induced cellular damage, inhibit formation kidney efficacy drug delivery as effective carriers. Additionally, by modifying physical chemical properties bacteria, effectively eliminate bacterial presence, thereby preventing severe complications. This review explores advancements technology related to early detection risk factors, diagnosis, treatment their associated Keywords: nanomaterials, stones, stress, biomaterial

Language: Английский

Citations

1
Emerging Roles of Nanozyme in Tumor Metabolism Regulation: Mechanisms, Applications, and Future Directions DOI
You Li, Bowen Fu, Wei Jiang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Nanozymes, nanomaterials with intrinsic enzyme activity, have garnered significant attention in recent years due to their catalytic abilities comparable natural enzymes, cost-effectiveness, high activities, and stability against environmental fluctuations. As functional analogs of nanozymes participate various critical metabolic processes, including glucose metabolism, lactate the maintenance redox homeostasis, all which are essential for normal cellular functions. However, disruptions these pathways frequently promote tumorigenesis progression, making them potential therapeutic targets. While several therapies targeting tumor metabolism currently clinical or preclinical stages, efficacy requires further enhancement. Consequently, that target regarded as a promising strategy. Despite extensive studies investigating application relevant reviews relatively scarce. This article first introduces physicochemical properties biological behaviors nanozymes. Subsequently, we analyze role explore applications therapy. In conclusion, this review aims foster innovative research related fields advance development nanozyme-based strategies cancer diagnostics therapeutics.

Language: Английский

Citations

0
ATP‐Exhausted Strategy Induced Anti‐Tumor Low‐Temperature Photothermal Therapy Based on Rare Earth Nanocrystals Modified Hollow Porous MnOx Nanozyme with TME‐Activated NIR‐II Imaging DOI Open Access
Xiaozhao Wang, Liqiang Jing,

Zhengtao Luo

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Insufficient adenosine triphosphate (ATP) can reduce the synthesis of heat‐stress‐induced heat shock proteins (HSPs) to promote efficiency mild photothermal therapy (mPTT), thus rational design ATP‐exhausted strategy based on nanotechnology is an effective approach resuscitate mPTT. Herein, Nd 3+ doped nanocrystals (NaYF 4 :Nd@CaF 2 , Nd‐NCs) modified hollow mesoporous manganese oxide (H‐MnO x ) nanocomposite @Nd‐NCs, MN) synthesized, and loaded with glucose transporters (GLUTs) inhibitor KL‐11743, noted as MN‐KL nanozyme. In tumor microenvironment (TME), react overexpressed glutathione (GSH) release which suppress intracellular ATP at source by blocking uptake inhibit HSPs expression, meanwhile, catalyzes production ·O − / 1 O /·OH lipid peroxidation (LPO) cleave existing HSPs. Through a two‐pronged inhibition accumulation, reducing level be guaranteed for achieving efficient mPTT in both subcutaneous situ models mice. During this process, Nd‐NCs absorb near‐infrared light convert it into heat, quenched fluorescence H‐MnO recovered through GSH‐triggered biodegradation tumors, modification not only provides effect but also enables MN own TME‐activated imaging.

Language: Английский

Citations

0
Bioinspired nanomedicines for the management of osteosarcoma: recent progress and perspectives DOI Creative Commons

K Cui,

Fei Ren, Jimmy C. Yu

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101607 - 101607

Published: March 5, 2025

Osteosarcoma (OS) is the most prevalent malignant primary bone tumor, predominantly affecting children and young adults between ages of 11 20. OS presents huge challenges in treatment because its aggressive nature high metastatic potential. Chemotherapeutic drugs have attracted considerable interest for OS, but they suffer from poor targeting, low bioavailability, severe side effects, multi-drug resistance acquired by tumor. Therefore, it imperative to develop novel therapeutic tactics that can improve outcomes while minimizing toxicity. Bioinspired nanoparticles, designed through exploiting or simulating biological structures processes, provide promising strategies OS. In this review, we elaborate on properties biomedical applications state-of-the-art bioinspired including cell membrane-based exosome-based protein template-based peptide nanoparticles management

Language: Английский

Citations

0
ROS-related nanoparticles for the management of Alzheimer’s disease: Wielding the double-edged sword DOI

Yibin Yu,

Qi Zhang, Yihao Guo

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161784 - 161784

Published: March 1, 2025

Language: Английский

Citations

0
Cyclodextrin-based nanotherapeutics: A promising strategy for enhanced cancer therapy DOI
Menglin Zhang,

Fanpeng Ran,

Yun Zhang

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111232 - 111232

Published: April 1, 2025

Language: Английский

Citations

0
Nanotechnology applications in the regulation of metabolic diseases DOI
Yan Li, Yongfei Fan, Haibo Yang

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 538, P. 216736 - 216736

Published: April 22, 2025

Language: Английский

Citations

0
Unlocking the Potential of Disulfidptosis: Nanotechnology‐Driven Strategies for Advanced Cancer Therapy DOI
Wenyao Zhen, Tianzhi Zhao, Xiaoyuan Chen

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Tumor tissues exhibit elevated oxidative stress, with the cystine‐glutamate transporter x CT solute carrier family 7 member 11 ( CT/SLC7A11) protecting cancer cells from damage by facilitating cystine uptake for glutathione synthesis. Disulfidptosis, a newly identified form of programmed cell death (PCD), occurs in high CT/SLC7A11 expression under glucose‐deprived conditions. Distinct other PCD pathways, disulfidptosis is characterized aberrant disulfide bond formation and cellular dysfunction, ultimately resulting death. This novel mechanism offers remarkable therapeutic potential targeting inherent stress vulnerabilities rapidly growing cells. Advances nanotechnology enable development nanomaterials capable inducing reactive oxygen species (ROS) generation, disrupting bonds. In addition, they are to deliver agents directly tumors, thereby improving precision minimizing off‐target effects. Moreover, combining ROS‐induced immunogenic can remodel tumor microenvironment enhance anti‐tumor immunity. review explores mechanisms underlying disulfidptosis, its treatment, synergistic role amplifying Selective induction using represents promising strategy achieving more effective, selective, less toxic therapies.

Language: Английский

Citations

0
Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration DOI Creative Commons

Churong Xu,

Fei Wu,

Zhouyi Duan

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 3, 2025

Language: Английский

Citations

0
The Transformative Role of Nanoenzymes in the Diagnosis, Targeted Treatment, and Prognosis of Ovarian Cancer. A comprehensive review DOI Creative Commons
Ahmed Imran,

Aqsa Gulzar,

Muhammad Rehman Gulzar

et al.

Developmental medico-life-sciences, Journal Year: 2024, Volume and Issue: 1(10), P. 4 - 22

Published: Dec. 13, 2024

Ovarian cancer is one of the most aggressive and deadly gynaecological malignancies remains frequently diagnosed at advanced stages because its asymptomatic progression inherent limitations current diagnostic tests. Nanoenzymes (a class nanotechnology-based artificial enzymes) have great promise in addressing these challenges. greatly improve sensitivity specificity biosensors including optical electrochemical systems, with real-time high-precision detection key biomarkers such as CA-125, HE4, mesothelin. The high accuracy biosensors, fluorescence surface plasmon resonance (SPR) based technologies, for early-stage diagnosis, cost-effective, portable, ultra-low limits make them attractive alternatives. Nanoenzyme-based drug delivery systems like liposomes, polymeric micelles, Nanocapsules therapeutic outcomes by allowing targeted transport to tumor tissues, reducing systemic toxicity, overcoming resistance treatment. PEGylated liposomal doxorubicin (Doxil), a formulation, has been shown enhanced efficacy platinum-resistant ovarian cancer, reduced adverse effects. Further theranostic applications metallic nanoparticles gold iron oxide can be realized using therapy imaging. These advancements come their challenges, however, biological barriers, scalability before clinical translation. Interdisciplinary research, validation, creation regulatory frameworks safety are needed future progress. offer revolutionize diagnosis treatment potential facilitate early detection, precision, patient outcome while filling huge gaps approaches.

Language: Английский

Citations

1