Allosteric release of cucurbit[6]uril from a rotaxane using a molecular signal DOI Creative Commons
Aneta Závodná, Petr Janovský,

Václav Kolařík

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Repulsions between portals of cucurbit[ n ]urils are sufficiently strong to unlock the rotaxane structure.

Language: Английский

Pseudo[3]rotaxane and [3]Rotaxane of Per(5-carboxy-5-dehydroxymethyl)-Cyclodextrins Utilizing Carboxylic Acid Dimer as Recognition Units DOI
Takashi Nakamura,

Masamune Kuwabara,

Haoyang Zhang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 90(10), P. 3603 - 3609

Published: March 5, 2025

The formation of pseudo[3]rotaxane using dimers per(5-carboxy-5-dehydroxymethyl)-cyclodextrins as ring components and secondary ammoniums an axle is presented. This supramolecule formed by the unique interaction circularly arranged carboxylic acid acting hydrogen bonding acceptors covering moiety. On these grounds, we could achieve synthesis [3]rotaxane capping terminal groups through thiol-ene reactions.

Language: Английский

Citations

0
A Thiourea-Based Rotaxane Catalyst: Nucleophilic Fluorination Phase-Transfer Process Unlocked by the Mechanical Bond DOI
Julio Puigcerver, Juan S. Dato-Santiago, Mateo Alajarı́n

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

We report a five-component clipping approach using activated isophthaloyl-derived esters to synthesize an amide-based thiourea rotaxane. This method overcomes acyl chloride limitations with nucleophilic threads. The steric hindrance of the mechanical bond enables, for first time, interlocked as hydrogen-bonding phase-transfer organocatalyst in fluorinations. highlights how bonds expand catalysis processes previously incompatible conventional catalysts.

Language: Английский

Citations

0
Click chemistry in tuberculosis research: From drug design to therapeutic delivery - A systematic review DOI Open Access
Zimo Ren, Paolo Coghi

European Journal of Chemistry, Journal Year: 2025, Volume and Issue: 16(1), P. 83 - 96

Published: March 31, 2025

The molecular hybridization of 1,2,3-triazoles with various bioactive scaffolds has become a promising approach to the development new antitubercular drugs, offering versatile platform for improving drug efficacy and specificity. This review covers key advancements over past decade in creating triazole-based hybrids that integrate azoles, coumarin/chromene, isoniazid, quinoline/dihydroquinoline, quinolone, ferrocene, isatin, furan, other structures. These hybrid molecules generally show improved potency against both drug-sensitive drug-resistant Mycobacterium tuberculosis strains while maintaining favorable toxicity profiles, making them particularly valuable current landscape rising resistance. Structure-activity relationship (SAR) studies highlight strategic substituent positioning optimal linker selection are critical enhancing antimycobacterial efficacy. Furthermore, modifications electronic steric properties have been shown influence their ability bypass common resistance mechanisms, underscoring potential these compounds overcome treatment barriers. In particular, several demonstrate activity MDR-TB XDR-TB strains, suggesting applications immunocompromised patients, such as those HIV co-infection. Collectively, findings offer insights rational design next-generation antituberculosis agents could transform (TB) paradigms resistant sensitive cases TB.

Language: Английский

Citations

0
Interlocking Pseudorotaxanes through Borane- and Boronic Ester-Mediated Carbon–Carbon Bond Formation DOI Creative Commons
Jia-Jyun Jian, Minxuan Zhang, Yi‐Hung Liu

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Employing 9-BBN and pinacol boronic ester as surrogate stoppers, pseudorotaxanes presenting terminal alkenes can be transformed into organoborane or organoboronate rotaxanes, respectively. Various boron-based reactions then used to replace these temporary stoppers with bulky derivatives of aromatic bromides, α-bromo ketones, 1-bromo-1-alkynes, facilitating the selective formation sp3-sp2, sp3-sp3, sp3-sp carbon-carbon single bonds,

Language: Английский

Citations

0
Cyclodextrin-based rotaxanes as a versatile platform for biological and medicinal applications DOI Creative Commons

Sapir Paryente,

Hajar Aledwan,

Abed Saady

et al.

Communications Chemistry, Journal Year: 2025, Volume and Issue: 8(1)

Published: May 13, 2025

Language: Английский

Citations

0
Emerging mechanically interlocked cages DOI

Enping Du,

Xianhui Tang, Wenqiang Zhang

et al.

Nature Reviews Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: June 5, 2025

Language: Английский

Citations

0
Topology Transformation of Macrocycles for the Construction of Dynamic Mechanically Interlocked Rotaxanes DOI

Chun-Lin Xiao,

Xue Li, Naotaka Okamoto

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Allosteric release of cucurbit[6]uril from a rotaxane using a molecular signal DOI Creative Commons
Aneta Závodná, Petr Janovský,

Václav Kolařík

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Repulsions between portals of cucurbit[ n ]urils are sufficiently strong to unlock the rotaxane structure.

Language: Английский

Citations

0