Trianthracene Derivative Based Nanoparticles for in vivo Afterglow Imaging of Traumatic Brain Injury DOI

Zaifeng Chen,

Yuzhen Yu, Long Deng

et al.

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Comprehensive Summary Traumatic brain injury (TBI) constitutes a cluster of disorders resulting from external physical forces that undermine the structure or function brain. TBI brings high disability and mortality rates to patients. Hence, early diagnosis is utmost importance. Current approaches mainly encompass computed tomography magnetic resonance imaging; however, there are still constraints in diagnosing due limited spatial resolution long scan durations. Herein, based on advantages low imaging background, signal‐to‐background ratio, excellent tissue penetration, sensitivity afterglow imaging, we have developed trianthracene derivative (TA)‐based nanoparticle for non‐invasive TBI. Compared with fluorescence TA‐NPs demonstrate deeper penetration depth (up 2.5 cm) higher signal‐to‐noise ratio. After injection via tail vein, can accumulate area within parenchyma achieve vivo detection short period (within 1 h), which beneficial Additionally, also accomplish precise injuries lower severity. The TA‐NPs‐based herein will significantly facilitate provide robust evidence its subsequent treatment.

Language: Английский

Chemiluminescent transition metal complexes: Mechanisms and applications DOI
Jinghui Zhu,

Mingrui Gu,

Yahui Chen

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216495 - 216495

Published: Feb. 5, 2025

Language: Английский

Citations

2
Ultralong Afterglow of Zinc(II) Halide Complexes Enabled by Regulating the Arrangements of N‐Methylbenzimidazole Ligands DOI
Guanghui Zhang, Hai‐Ling Wang, Yun‐Lan Li

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract In this study, a simple and rapid strategy is developed for the gram‐scale synthesis of zinc(II) halide complexes with ultralong afterglow under mild conditions. Crystalline, high‐purity are synthesized using N ‐methylbenzimidazole ( Bz ) common zinc salts (ZnX 2 , X = Cl, Br, I) as cheap industrial raw materials by stirring at room temperature atmospheric pressure. By exploiting steric effect terminal‐coordinated halogen ions to regulate arrangements ligands in structure complexes, namely cis ‐butterfly, trans cross ‐arrangement, completely differentiated stacking modes obtained. Zn(Bz)Cl ‐butterfly‐shaped arrangement has longest room‐temperature phosphorescence (RTP) lifetime (505.01 ms 298 K) long up 1.4 s. This study proposes first time use end group coordination fluorophores within resulting considerably improved RTP afterglow, thus providing new platform large‐scale afterglow.

Language: Английский

Citations

1
Recent advances and design strategies for organic afterglow agents to enhance autofluorescence-free imaging performance DOI

Jieli Zhu,

Lei Zhao,

Wen An

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Organic afterglow luminescence can emit light long after the cessation of irradiation, enabling autofluorescence-free in vivo imaging with high signal-to-background ratios (SBRs).

Language: Английский

Citations

4
Photochemical afterglow with ultrabright lanthanide luminescence for homogeneous immunoassay DOI
Xiao Chen,

Chunling Li,

Ming Xu

et al.

Journal of Rare Earths, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Trianthracene Derivative Based Nanoparticles for in vivo Afterglow Imaging of Traumatic Brain Injury DOI

Zaifeng Chen,

Yuzhen Yu, Long Deng

et al.

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Comprehensive Summary Traumatic brain injury (TBI) constitutes a cluster of disorders resulting from external physical forces that undermine the structure or function brain. TBI brings high disability and mortality rates to patients. Hence, early diagnosis is utmost importance. Current approaches mainly encompass computed tomography magnetic resonance imaging; however, there are still constraints in diagnosing due limited spatial resolution long scan durations. Herein, based on advantages low imaging background, signal‐to‐background ratio, excellent tissue penetration, sensitivity afterglow imaging, we have developed trianthracene derivative (TA)‐based nanoparticle for non‐invasive TBI. Compared with fluorescence TA‐NPs demonstrate deeper penetration depth (up 2.5 cm) higher signal‐to‐noise ratio. After injection via tail vein, can accumulate area within parenchyma achieve vivo detection short period (within 1 h), which beneficial Additionally, also accomplish precise injuries lower severity. The TA‐NPs‐based herein will significantly facilitate provide robust evidence its subsequent treatment.

Language: Английский

Citations

0