Adhesive transparent antimicrobial quaternized chitosan/oxidized dextran/polydopamine nanoparticle hydrogels for accelerated wound healing
Pu Hou,
No information about this author
Kun Lei,
No information about this author
Zhishen Zhang
No information about this author
et al.
Biomaterials Advances,
Journal Year:
2025,
Volume and Issue:
169, P. 214176 - 214176
Published: Jan. 9, 2025
Language: Английский
Glucose-Regulating Hydrogel for Immune Modulation and Angiogenesis through Metabolic Reprogramming and LARP7-SIRT1 Pathway in Infected Diabetic Wounds
Yuheng Liao,
No information about this author
Zhenhe Zhang,
No information about this author
Weixian Hu
No information about this author
et al.
Biomaterials,
Journal Year:
2025,
Volume and Issue:
318, P. 123182 - 123182
Published: Feb. 11, 2025
Language: Английский
An injectable reactive oxygen species-responsive self-assembled hydrogel loaded with L-glutamine targets cartilage repair for treatment of osteoarthritis
Chen Wang,
No information about this author
Junyan He,
No information about this author
Zhongyao Hu
No information about this author
et al.
Chemical Engineering Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 159529 - 159529
Published: Jan. 1, 2025
Language: Английский
Disclosing long-term tolerance, efficacy and penetration properties of hyaluronic acid-coated latanoprost-loaded liposomes as chronic glaucoma therapy
Journal of Controlled Release,
Journal Year:
2025,
Volume and Issue:
379, P. 730 - 742
Published: Jan. 25, 2025
Language: Английский
Hybrid hydrogel based on porcine-derived matrix with gallic acid and cerium-doped mesoporous bioactive glass for diabetic wound healing
Haozeng,
No information about this author
Qinghong Lai,
No information about this author
Wanyou Liao
No information about this author
et al.
Materials & Design,
Journal Year:
2025,
Volume and Issue:
unknown, P. 113714 - 113714
Published: Feb. 1, 2025
Language: Английский
Terbinafine-loaded biocompatible hydrogel patches composed of hydroxyethyl methacrylate and methacrylic acid with remarkable antifungal activities
Macromolecular Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 7, 2025
Language: Английский
Combined treatment strategy of hydrogel dressing and physiotherapy for rapid wound healing
Xiaofei Xie,
No information about this author
Chenhui Zhu,
No information about this author
Jing Zhao
No information about this author
et al.
Advances in Colloid and Interface Science,
Journal Year:
2025,
Volume and Issue:
unknown, P. 103477 - 103477
Published: March 1, 2025
Language: Английский
A Visible-Light Photocatalysis/Hydrolysis Hydrogen-Generating Nanoplatform for Dynamic Inflammation Management via Immune Metabolism Orchestration during Wound Repair
Zhaoyu Xu,
No information about this author
Yang Yang,
No information about this author
Xinhui Li
No information about this author
et al.
ACS Applied Materials & Interfaces,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 21, 2025
Effective
management
of
inflammation
is
one
the
promising
strategies
to
prevent
formation
chronic
wounds.
Despite
hydrogen
being
a
prospective
molecule
for
anti-inflammatory
effects,
on-demand
delivery
that
could
synchronize
with
dynamic
stages
has
yet
remained
unaddressed.
Moreover,
its
specific
immunomodulatory
mechanisms
are
still
veiled.
In
this
study,
we
introduced
ISO-ZIF-8@AB,
hydrogen-generating
nanoplatform
integrated
visible-light
photocatalysis
and
hydrolysis
reactions
achieve
controllable
release
on
demand,
functioning
an
initial
peak
following
sustained
release.
With
ISO-ZIF-8@AB
further
loaded
into
aligned
ECM-like
scaffold,
complex
significantly
alleviated
prevented
protracted
unhealing.
The
bulk-RNA
sequencing
combined
single-cell
RNA
revealed
treatment
effectively
reduced
excessive
aggregation
infiltration
innate
immune
cells.
Specifically,
proportion
Ptgs2+Nos2+
pro-inflammatory
macrophages
(PIMs)
by
mitigating
mitochondrial
stress
suppressing
HIF-1α-induced
glycolysis,
immune-metabolic
regulation
which
harmful
crosstalk
between
PIMs
hypodermal
fibroblasts
facilitated
extracellular
matrix
production
accompanied
ultimate
wound
repair.
Overall,
study
presented
strategy
in
terms
timing
rate,
discussions
regarding
underlying
therapy.
Language: Английский
Engineered Exosomes Loaded in Intrinsic Immunomodulatory Hydrogels with Promoting Angiogenesis for Programmed Therapy of Diabetic Wounds
Wei‐Chien Huang,
No information about this author
Qianru Guo,
No information about this author
Hongrong Wu
No information about this author
et al.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 6, 2025
Inducing
rapid
angiogenesis
by
delivering
specific
biological
cues
is
critical
for
diabetic
wound
healing.
Nevertheless,
the
hindered
inflammatory
microenvironment,
and
immune
cells
fail
to
orchestrate
responses
Herein,
vascular
endothelial
growth
factor
(VEGF)
plasmids-loaded
macrophage
exosomes
(Exos)
were
fabricated
enfolded
in
injectable
self-healing
hydrogels
programmed
therapy
of
wounds
through
sequentially
intrinsically
modulating
microenvironment
promoting
angiogenesis.
The
hydrogels,
formed
via
dynamical
Schiff
base
reactions
using
modified
polysaccharides,
regulate
broad-spectrum
antioxidant
activity
phenotype
regulation,
restoring
tissue
redox
homeostasis.
Furthermore,
can
stabilize
release
engineered
exosomes.
By
integration
generation
VEGF
Exos,
secretion
M2
macrophages,
enhanced
binding
receptor
2
high
affinity
sulfated
chitosan,
intrinsic
immunomodulatory
effectively
promote
accelerate
healing
process.
Language: Английский
Review of Metal–Polyphenol Self-Assembled Nanoparticles: Synthesis, Properties, and Biological Applications in Inflammatory Diseases
ACS Biomaterials Science & Engineering,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 25, 2025
Polyphenols,
which
are
compounds
characterized
by
the
presence
of
phenolic
hydroxyl
groups,
abundantly
found
in
natural
plants
and
exist
highly
complex
forms
within
living
organisms.
As
some
most
prevalent
nature,
polyphenols
possess
significant
medicinal
value
due
to
their
unique
structural
features,
particularly
therapeutic
efficacy
antitumor,
anti-inflammatory,
antibacterial
applications.
In
context
inflammation
therapy,
polyphenolic
can
inhibit
excessive
release
inflammatory
mediators
from
cells,
thereby
mitigating
inflammation.
Furthermore,
these
exhibit
strong
antioxidant
properties,
enabling
them
scavenge
free
radicals
reactive
oxygen
species
(ROS),
reduce
oxidative
stress-related
damage,
exert
anti-inflammatory
effects.
Due
multiple
groups
ability
chelate
various
metals,
extensively
utilized
synthesis
self-assembled
nanoparticles
for
treatment
diseases.
Numerous
studies
have
demonstrated
that
profile
formed
through
self-assembly
with
metal
ions
surpasses
alone.
This
Review
will
focus
on
different
generate
nanoparticles,
characterization,
applications
inflammation-related
diseases,
providing
researchers
new
insights
into
synthetic
study
metal-polyphenol
nanocomposites
biological
Language: Английский