Review of Metal–Polyphenol Self-Assembled Nanoparticles: Synthesis, Properties, and Biological Applications in Inflammatory Diseases DOI
Huiying Li, Shuang Li, Jiawei Du

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Polyphenols, which are compounds characterized by the presence of phenolic hydroxyl groups, abundantly found in natural plants and exist highly complex forms within living organisms. As some most prevalent nature, polyphenols possess significant medicinal value due to their unique structural features, particularly therapeutic efficacy antitumor, anti-inflammatory, antibacterial applications. In context inflammation therapy, polyphenolic can inhibit excessive release inflammatory mediators from cells, thereby mitigating inflammation. Furthermore, these exhibit strong antioxidant properties, enabling them scavenge free radicals reactive oxygen species (ROS), reduce oxidative stress-related damage, exert anti-inflammatory effects. Due multiple groups ability chelate various metals, extensively utilized synthesis self-assembled nanoparticles for treatment diseases. Numerous studies have demonstrated that profile formed through self-assembly with metal ions surpasses alone. This Review will focus on different generate nanoparticles, characterization, applications inflammation-related diseases, providing researchers new insights into synthetic study metal-polyphenol nanocomposites biological

Language: Английский

Adhesive transparent antimicrobial quaternized chitosan/oxidized dextran/polydopamine nanoparticle hydrogels for accelerated wound healing DOI

Pu Hou,

Kun Lei,

Zhishen Zhang

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 169, P. 214176 - 214176

Published: Jan. 9, 2025

Language: Английский

Citations

1
Glucose-Regulating Hydrogel for Immune Modulation and Angiogenesis through Metabolic Reprogramming and LARP7-SIRT1 Pathway in Infected Diabetic Wounds DOI

Yuheng Liao,

Zhenhe Zhang, Weixian Hu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123182 - 123182

Published: Feb. 11, 2025

Language: Английский

Citations

1
An injectable reactive oxygen species-responsive self-assembled hydrogel loaded with L-glutamine targets cartilage repair for treatment of osteoarthritis DOI Creative Commons
Chen Wang, Junyan He,

Zhongyao Hu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159529 - 159529

Published: Jan. 1, 2025

Language: Английский

Citations

0
Disclosing long-term tolerance, efficacy and penetration properties of hyaluronic acid-coated latanoprost-loaded liposomes as chronic glaucoma therapy DOI
Marco Brugnera, Marta Vicario‐de‐la‐Torre, Miriam Ana González-Cela-Casamayor

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 730 - 742

Published: Jan. 25, 2025

Language: Английский

Citations

0
Hybrid hydrogel based on porcine-derived matrix with gallic acid and cerium-doped mesoporous bioactive glass for diabetic wound healing DOI Creative Commons

Haozeng,

Qinghong Lai,

Wanyou Liao

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113714 - 113714

Published: Feb. 1, 2025

Language: Английский

Citations

0
Terbinafine-loaded biocompatible hydrogel patches composed of hydroxyethyl methacrylate and methacrylic acid with remarkable antifungal activities DOI Creative Commons
Kemal Çetin, Koray Şarkaya, Fatih Altıntaş

et al.

Macromolecular Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Language: Английский

Citations

0
Combined treatment strategy of hydrogel dressing and physiotherapy for rapid wound healing DOI

Xiaofei Xie,

Chenhui Zhu,

Jing Zhao

et al.

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 103477 - 103477

Published: March 1, 2025

Language: Английский

Citations

0
A Visible-Light Photocatalysis/Hydrolysis Hydrogen-Generating Nanoplatform for Dynamic Inflammation Management via Immune Metabolism Orchestration during Wound Repair DOI

Zhaoyu Xu,

Yang Yang,

Xinhui Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Effective management of inflammation is one the promising strategies to prevent formation chronic wounds. Despite hydrogen being a prospective molecule for anti-inflammatory effects, on-demand delivery that could synchronize with dynamic stages has yet remained unaddressed. Moreover, its specific immunomodulatory mechanisms are still veiled. In this study, we introduced ISO-ZIF-8@AB, hydrogen-generating nanoplatform integrated visible-light photocatalysis and hydrolysis reactions achieve controllable release on demand, functioning an initial peak following sustained release. With ISO-ZIF-8@AB further loaded into aligned ECM-like scaffold, complex significantly alleviated prevented protracted unhealing. The bulk-RNA sequencing combined single-cell RNA revealed treatment effectively reduced excessive aggregation infiltration innate immune cells. Specifically, proportion Ptgs2+Nos2+ pro-inflammatory macrophages (PIMs) by mitigating mitochondrial stress suppressing HIF-1α-induced glycolysis, immune-metabolic regulation which harmful crosstalk between PIMs hypodermal fibroblasts facilitated extracellular matrix production accompanied ultimate wound repair. Overall, study presented strategy in terms timing rate, discussions regarding underlying therapy.

Language: Английский

Citations

0
Engineered Exosomes Loaded in Intrinsic Immunomodulatory Hydrogels with Promoting Angiogenesis for Programmed Therapy of Diabetic Wounds DOI
Wei‐Chien Huang,

Qianru Guo,

Hongrong Wu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 6, 2025

Inducing rapid angiogenesis by delivering specific biological cues is critical for diabetic wound healing. Nevertheless, the hindered inflammatory microenvironment, and immune cells fail to orchestrate responses Herein, vascular endothelial growth factor (VEGF) plasmids-loaded macrophage exosomes (Exos) were fabricated enfolded in injectable self-healing hydrogels programmed therapy of wounds through sequentially intrinsically modulating microenvironment promoting angiogenesis. The hydrogels, formed via dynamical Schiff base reactions using modified polysaccharides, regulate broad-spectrum antioxidant activity phenotype regulation, restoring tissue redox homeostasis. Furthermore, can stabilize release engineered exosomes. By integration generation VEGF Exos, secretion M2 macrophages, enhanced binding receptor 2 high affinity sulfated chitosan, intrinsic immunomodulatory effectively promote accelerate healing process.

Language: Английский

Citations

0
Review of Metal–Polyphenol Self-Assembled Nanoparticles: Synthesis, Properties, and Biological Applications in Inflammatory Diseases DOI
Huiying Li, Shuang Li, Jiawei Du

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Polyphenols, which are compounds characterized by the presence of phenolic hydroxyl groups, abundantly found in natural plants and exist highly complex forms within living organisms. As some most prevalent nature, polyphenols possess significant medicinal value due to their unique structural features, particularly therapeutic efficacy antitumor, anti-inflammatory, antibacterial applications. In context inflammation therapy, polyphenolic can inhibit excessive release inflammatory mediators from cells, thereby mitigating inflammation. Furthermore, these exhibit strong antioxidant properties, enabling them scavenge free radicals reactive oxygen species (ROS), reduce oxidative stress-related damage, exert anti-inflammatory effects. Due multiple groups ability chelate various metals, extensively utilized synthesis self-assembled nanoparticles for treatment diseases. Numerous studies have demonstrated that profile formed through self-assembly with metal ions surpasses alone. This Review will focus on different generate nanoparticles, characterization, applications inflammation-related diseases, providing researchers new insights into synthetic study metal-polyphenol nanocomposites biological

Language: Английский

Citations

0