Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111404 - 111404
Published: June 1, 2025
Language: Английский
ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(10), P. 741 - 741
Published: May 19, 2025
Tumor-associated macrophages’ (TAMs) origin, polarization, and dynamic interaction in the tumor microenvironment (TME) influence cancer development. They are essential for homeostasis, monitoring, immune protection. Cells from bone marrow or embryonic progenitors dynamically polarize into pro- anti-tumor M2 M1 phenotypes based on cytokines metabolic signals. Recent advances TAM heterogeneity, characterization, immunological responses, therapy described here. The manuscript details functions their role resistance to PD-1/PD-L1 blockade. Similarly, TAM-targeted approaches, such as CSF-1R inhibition PI3Kγ-driven reprogramming, discussed address immunity suppression. Furthermore, innovative biomarkers combination may enhance TAM-centric therapies. It also stresses relevance of this distinct cell human health disease, which could impact future research
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 541, P. 216806 - 216806
Published: May 21, 2025
Language: Английский
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0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: May 23, 2025
Abstract Immunotherapy represents a highly promising modality in cancer treatment, with substantial advancements therapeutic strategies. The primary challenge lies enhancing the efficacy of immunotherapy approaches. Here, novel cryo‐inactivated cells (CICC) derived magnetic micromotors (CICC@FeMnP) are reported for tumor synergistic immunotherapy. Through control, CICC@FeMnP can on‐demand target and accumulate at site. FeMnP induce ferroptosis then trigger immunogenic cell death cells. CICC containing whole antigen conduct vaccination effects. Together Mn 2+ ‐mediated cGAS‐STING pathway to stimulate immune response, anti‐tumor effects be achieved. Importantly, not only facilitate establishment collaborative network enhance effective tumoricidal immunity but also long‐lasting memory These results contribute inhibition progression, recurrence lung metastasis, thereby prolonging overall survival tumor‐bearing mice. This work underscores potential an engineered biohybrid micromotor system as alternative approach against tumors.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: May 24, 2025
Abstract Effective initiation of the cancer‐immunity cycle is core challenge tumor immunotherapy, which relies on coordinated antigen release and immunostimulation. To address this issue, work introduced a novel lymphocyte‐mimicking sonosensitizer using Mn‐doped hollow Prussian blue nanoparticle (Mn‐HP) for cancer sonodynamic therapy (SDT) to efficiently evoke anticancer immunity. The prepared Mn‐HP have unique architecture amplify ultrasonic cavitation effects, boosting spatially controlled reactive oxygen species (ROS) production. Through effective combination lymphocytes, Lymphocyte‐mimicking (Lymphocytes‐Mn‐HP, LM) with “Homing effect” constructed. sequenced dual‐ultrasound strategy employs high‐power ultrasound (2.0 W cm −2 ) stimulation (excessive ROS) low‐power (0.5 (moderate lymph node active immune cells, enabling precise spatial‐temporal ROS generation while preserving function. Both in vitro vivo studies demonstrated significant suppression through initiating cycle, offering transformative paradigm SDT‐immunotherapy integration.
Language: Английский
Citations
0
Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107811 - 107811
Published: June 1, 2025
Neutrophils are an important component of the tumor microenvironment, with majority previous research concentrating on their anti-tumor role. Recent indicates that elevated neutrophil-lymphocyte ratios indicative worse cancer prognoses. In addition, it revealed functional transition neutrophils related metabolic regulation within microenvironment.The metabolic-immune axis has emerged as a master regulator progression, yet role neutrophil-centric crosstalk in this paradigm remains enigmatic. Therefore, study highlights innovative tumorigenesis, particularly regulatory effect niche transformation after glucose metabolism reprogramming. Simultaneously, we discussed how microenvironment alters neutrophils, influences life cycle, and modifies localization activity inside niche. targeted including new therapies clinical trials, offer possibilities for treatment. This work establishes neutrophil glycolysis linchpin ecosystem provides combinatorial therapeutic blueprint to dismantle pro-tumorigenic niches.
Language: Английский
Citations
0
Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111404 - 111404
Published: June 1, 2025
Language: Английский
Citations
0