Ru(II)-Fenamic-Based Complexes as Promising Human Ovarian Antitumor Agents: DNA Interaction, Cellular Uptake, and Three-Dimensional Spheroid Models

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Cancer resistance to chemotherapeutic agents such as cisplatin presents a significant challenge, leading treatment failure and poor outcomes. Novel metal-based compounds offer promising strategy overcome drug enhance efficacy. Four Ru(II) complexes with fenamic acid derivatives were synthesized characterized: [Ru(L)(bipy)(dppp)]PF6, where L represents (HFen, complex 1), mefenamic (HMFen, 2), tolfenamic (HTFen, 3), flufenamic (HFFen, 4). Their composition was supported by molar conductivity, elemental analysis, Fourier transform infrared spectroscopy, ultraviolet–visible mass spectrometry, 31P{1H}, 1H, 13C nuclear magnetic resonance, the crystal structure of 1 confirmed via X-ray diffraction. Complexes 1–4 exhibited notable cytotoxicity against tested cell lines, particularly A2780 A2780cisR (cisplatin-resistant ovarian tumors), compared MDA-MB-231 (breast) A549 (lung) lines. Mechanistic studies revealed weak DNA interactions through minor grooves or electrostatic binding. Cellular uptake assays showed effective internalization (3.6%) 2 (4.5%), correlating potent IC50 values. These also altered morphology, reduced density, inhibited colony formation in cells. Staining indicated induced death organelle damage, highlighting their potential antitumor agents.

Language: Английский

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Synthesis of N-heterocyclic carbene‑selenium complexes modulating apoptosis and autophagy in cancer cells: Probing the interactions with biomolecules and enzymes

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 160, P. 108435 - 108435

Published: April 5, 2025

Language: Английский

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Ruthenium(II)-mercapto complexes induce cell damage via apoptosis pathway on ovarian cancer cells

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 265, P. 112819 - 112819

Published: Dec. 30, 2024

Language: Английский

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Ru(II)-Diphosphine/N,S-Mercapto Complexes and Their Anti-melanoma Properties

Dalton Transactions, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

We have synthesized and characterized a novel series of ruthenium complexes with formulas [RuCl(N-S)(dppm)

Language: Английский

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