Introduction of a Phosphine Group onto the Ferrocene Moiety in Ferrociphenol Opens Access to New Heterobimetallic Complexes with Anticancer Activity DOI Creative Commons

Magda Křelinová,

Michèle Salmain, Petr Štěpnička

et al.

ChemistryEurope, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Ferrocene analogs of biologically active compounds often exert favorable properties, as demonstrated by ferrocifens derived from the selective estrogen receptor modulator tamoxifen. This contribution reports an original approach to modify structure one first ferrocifens, namely ferrociphenol, means a diphenylphosphinyl moiety appended unsubstituted cyclopentadienyl ring ferrocene unit. The phosphine‐substituted ferrociphenol 1 is synthesized two alternative routes and fully characterized including determination. Compound converted corresponding phosphonium salt ·MeI used prepare series bimetallic (arene)metal chloridogold(I) complexes. biological evaluation reveals relatively lower antiproliferative activity newly compared parent [AuCl(FcPPh 2 ‐κ P )] (Fc = ferrocenyl) toward both tumorigenic nontumorigenic cells. All exhibit complicated redox behavior due chemical steps that follow initial, ferrocene‐centered oxidation. Overall, collected data indicate introduced phosphine substituent affects properties resulting and, very likely, their mode action.

Language: Английский

Changing the properties of monodentate and P,C-chelating ferrocenyl-substituted 1,2,3-triazol-5-ylidene ligands through an inserted carbonyl moiety DOI Creative Commons

Věra Varmužová,

Ivana Cı́sařová, Petr Štěpnička

et al.

Dalton Transactions, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Introduction of a carbonyl linker and phosphinyl moiety into the molecule ferrocene triazolylidene changes donor properties this ligand unlocks access to unique, redox-active P,C-chelating ligands, respectively.

Language: Английский

Citations

0
Introduction of a Phosphine Group onto the Ferrocene Moiety in Ferrociphenol Opens Access to New Heterobimetallic Complexes with Anticancer Activity DOI Creative Commons

Magda Křelinová,

Michèle Salmain, Petr Štěpnička

et al.

ChemistryEurope, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Ferrocene analogs of biologically active compounds often exert favorable properties, as demonstrated by ferrocifens derived from the selective estrogen receptor modulator tamoxifen. This contribution reports an original approach to modify structure one first ferrocifens, namely ferrociphenol, means a diphenylphosphinyl moiety appended unsubstituted cyclopentadienyl ring ferrocene unit. The phosphine‐substituted ferrociphenol 1 is synthesized two alternative routes and fully characterized including determination. Compound converted corresponding phosphonium salt ·MeI used prepare series bimetallic (arene)metal chloridogold(I) complexes. biological evaluation reveals relatively lower antiproliferative activity newly compared parent [AuCl(FcPPh 2 ‐κ P )] (Fc = ferrocenyl) toward both tumorigenic nontumorigenic cells. All exhibit complicated redox behavior due chemical steps that follow initial, ferrocene‐centered oxidation. Overall, collected data indicate introduced phosphine substituent affects properties resulting and, very likely, their mode action.

Language: Английский

Citations

0