Fighting Cancer with Photodynamic Therapy and Nanotechnologies: Current Challenges and Future Directions

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2969 - 2969

Published: March 25, 2025

Photodynamic therapy (PDT) is an innovative treatment that has recently been approved for clinical use and holds promise cancer patients. It offers several benefits, such as low systemic toxicity, minimal invasiveness, the ability to stimulate antitumor immune responses. For certain types of cancer, it shown positive results with few side effects. However, PDT still faces some challenges, including limited light penetration into deeper tumor tissues, uneven distribution photosensitizer (PS) can also affect healthy cells, difficulties posed by hypoxic microenvironment (TME). In conditions, PDT's effectiveness reduced due insufficient production reactive oxygen species, which limits destruction lead relapse. This review highlights recent advances in photosensitizers nanotechnologies are being developed improve PDT. focuses on multifunctional nanoplatforms nanoshuttles have preclinical studies, especially treating solid tumors. One key areas focus development PSs specifically target mitochondria treat deep-seated malignant New mitochondria-targeting nano-PSs designed better water solubility extended wavelength ranges, allowing them tumors more effectively, even challenging, environments. These advancements opening new doors treatment, when combined other therapeutic strategies. Moving forward, research should optimizing PDT, creating efficient drug delivery systems, developing smarter platforms. Ultimately, these efforts aim make a first-choice option

Language: Английский

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Chlorin e6: a promising photosensitizer of anti-tumor and anti-inflammatory effects in PDT

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 29, 2025

Photodynamic therapy (PDT) involves the activation of photosensitizers (PSs) by visible laser light at target site to catalyze production reactive oxygen species, resulting in tumor cell death and blood vessel closure. The efficacy PDT depends on PSs, amount oxygen, intensity excitation laser. PSs have been extensively researched, great efforts made develop an ideal photosensitizer. Chlorin-e6 is FDA-approved second-generation that has attracted widespread research interest medical field, especially with respect antitumor anti-inflammatory activity. possesses advantages a large absorption coefficient, high strength, low residue body, relatively safety thus promising application prospects. Here we review use chlorin-e6 discuss prospects further development this technology.

Language: Английский

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Recent progress in hyaluronic acid based nanoparticles for the anti-tumor application

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114860 - 114860

Published: June 1, 2025

Language: Английский

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The role of metal nanocarriers, liposomes and chitosan-based nanoparticles in diabetic retinopathy treatment: A review study

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139017 - 139017

Published: Dec. 1, 2024

Language: Английский

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