The gender difference in the effects of air pollution on the risk of spinal osteoarthritis in Chinese middle-aged and older adults: a prospective cohort study in China DOI Creative Commons
Jian Zhou,

Guanghui Guo,

Tao Liu

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: April 30, 2025

This study aimed to investigate whether exposure multiple ambient air pollutants (PM1, PM2.5, PM10, O₃, and NO₂) elevates the risk of spinal osteoarthritis among middle-aged older adults in China, further determine if there are gender-specific differences vulnerability. A total 7,663 participants aged 45 years older, drawn from China Health Retirement Longitudinal Study (CHARLS), were followed 2011 2020. Individuals free at baseline included. Annual mean concentrations PM1, NO₂ extracted High Air Pollutants (CHAP) dataset a 1 km resolution (10 for some years). Spinal was identified via self-reported, physician-diagnosed cases involving spine. Time-varying Cox proportional hazards regression models used evaluate hazard ratios (HR) 95% confidence intervals (CI) per 10 μg/m3 increase pollutant concentrations. All analyses accounted demographic, socioeconomic, lifestyle, spatial/seasonal factors, explored potential effect modification by gender. During median 7-year (IQR: 4-9 years) follow-up, 1,556 newly reported osteoarthritis. After adjusting confounders, each increment associated with significant rise incidence (13.8, 6.8, 5.1, 17.4%, respectively), while O₃ showed weaker non-significant (1.1%). Notably, stratified revealed that female exhibited pronounced vulnerability exposures, whereas associations males not statistically significant. prospective indicates higher particulate matter traffic-related may contribute an elevated osteoarthritis, particularly women. These findings underscore importance incorporating musculoskeletal health into quality management highlight value targeted interventions-such as reducing pollution monitoring high-risk groups-to mitigate burden rapidly urbanizing areas.

Language: Английский

The gender difference in the effects of air pollution on the risk of spinal osteoarthritis in Chinese middle-aged and older adults: a prospective cohort study in China DOI Creative Commons
Jian Zhou,

Guanghui Guo,

Tao Liu

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: April 30, 2025

This study aimed to investigate whether exposure multiple ambient air pollutants (PM1, PM2.5, PM10, O₃, and NO₂) elevates the risk of spinal osteoarthritis among middle-aged older adults in China, further determine if there are gender-specific differences vulnerability. A total 7,663 participants aged 45 years older, drawn from China Health Retirement Longitudinal Study (CHARLS), were followed 2011 2020. Individuals free at baseline included. Annual mean concentrations PM1, NO₂ extracted High Air Pollutants (CHAP) dataset a 1 km resolution (10 for some years). Spinal was identified via self-reported, physician-diagnosed cases involving spine. Time-varying Cox proportional hazards regression models used evaluate hazard ratios (HR) 95% confidence intervals (CI) per 10 μg/m3 increase pollutant concentrations. All analyses accounted demographic, socioeconomic, lifestyle, spatial/seasonal factors, explored potential effect modification by gender. During median 7-year (IQR: 4-9 years) follow-up, 1,556 newly reported osteoarthritis. After adjusting confounders, each increment associated with significant rise incidence (13.8, 6.8, 5.1, 17.4%, respectively), while O₃ showed weaker non-significant (1.1%). Notably, stratified revealed that female exhibited pronounced vulnerability exposures, whereas associations males not statistically significant. prospective indicates higher particulate matter traffic-related may contribute an elevated osteoarthritis, particularly women. These findings underscore importance incorporating musculoskeletal health into quality management highlight value targeted interventions-such as reducing pollution monitoring high-risk groups-to mitigate burden rapidly urbanizing areas.

Language: Английский

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