Application of Nanomaterials in the Diagnosis and Treatment of Retinal Diseases DOI

Yufei Yao,

Qiannan Cao,

Huapan Fang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract In recent years, nanomaterials have demonstrated broad prospects in the diagnosis and treatment of retinal diseases due to their unique physicochemical properties, such as small‐size effects, high biocompatibility, functional surfaces. Retinal are often accompanied by complex pathological microenvironments, where conventional diagnostic therapeutic approaches face challenges low drug delivery efficiency, risks associated with invasive procedures, difficulties real‐time monitoring. Nanomaterials hold promise addressing these limitations traditional therapies, thereby improving precision efficacy. The applications diagnostics summarized, they enable high‐resolution imaging carrying fluorescent probes or contrast agents act biosensors sensitively detect disease‐related biomarkers, facilitating early dynamic therapeutics, functionalized nanocarriers can precisely deliver drugs, genes, antioxidant molecules target cells, significantly enhancing outcomes while reducing systemic toxicity. Additionally, nanofiber materials possess properties that make them particularly suitable for regeneration tissue engineering. By loading neurotrophic factors into scaffolds, regenerative effects be amplified, promoting repair neurons. Despite immense potential, clinical translation still requires long‐term biosafety, scalable manufacturing processes, optimization targeting efficiency.

Language: Английский

PathoSense: a rapid optical aptasensing platform for monitoring Staphylococcus aureus in milk DOI Open Access
Najeeb Ullah, Tracy Ann Bruce‐Tagoe,

George Adu Asamoah

et al.

Journal of Chemical Technology & Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract BACKGROUND Staphylococcus aureus presents a major public health and food safety challenge due to its ability thrive in various environments. Conventional methods, such as polymerase chain reaction enzyme‐linked immunosorbent assay, often suffer from limitations sensitivity specificity, highlighting the need for innovative detection strategies. RESULTS This study developed novel label‐free aptasensors S. using copper nanoparticles (CuNPs) platform. The CuNPs, characterized by size of 40 nm, spherical morphology, functional stability, served foundation biosensor. An iron‐regulated surface determinant protein A (IsdA)‐binding aptamer, specifically targeting IsdA , was conjugated CuNPs molecular recognition probe, while rhodamine 6G acted signal probe. In absence aptamer kept ‘gate’ on closed, preventing probe release. presence specific binding between pathogen triggered open, releasing generating fluorescence signal. demonstrated linear range (10–10 6 ) CFU mL −1 with limit 1 (correlation coefficient R 2 = 0.947). biosensor high stability reproducibility, ensuring consistent performance. Furthermore, application milk samples highlighted practical utility. CONCLUSION These findings establish CuNP‐based aptasensor promising tool sensitive reliable detection, potential applications monitoring health. © 2025 Society Chemical Industry (SCI).

Language: Английский

Citations

0
Application of Nanomaterials in the Diagnosis and Treatment of Retinal Diseases DOI

Yufei Yao,

Qiannan Cao,

Huapan Fang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract In recent years, nanomaterials have demonstrated broad prospects in the diagnosis and treatment of retinal diseases due to their unique physicochemical properties, such as small‐size effects, high biocompatibility, functional surfaces. Retinal are often accompanied by complex pathological microenvironments, where conventional diagnostic therapeutic approaches face challenges low drug delivery efficiency, risks associated with invasive procedures, difficulties real‐time monitoring. Nanomaterials hold promise addressing these limitations traditional therapies, thereby improving precision efficacy. The applications diagnostics summarized, they enable high‐resolution imaging carrying fluorescent probes or contrast agents act biosensors sensitively detect disease‐related biomarkers, facilitating early dynamic therapeutics, functionalized nanocarriers can precisely deliver drugs, genes, antioxidant molecules target cells, significantly enhancing outcomes while reducing systemic toxicity. Additionally, nanofiber materials possess properties that make them particularly suitable for regeneration tissue engineering. By loading neurotrophic factors into scaffolds, regenerative effects be amplified, promoting repair neurons. Despite immense potential, clinical translation still requires long‐term biosafety, scalable manufacturing processes, optimization targeting efficiency.

Language: Английский

Citations

0