eGastroenterology, Journal Year: 2024, Volume and Issue: 2(4), P. e100129 - e100129

Published: Dec. 1, 2024

The intestinal epithelium serves as an essential interface between the host and microbiota, regulating innate adaptive immunity, absorption of nutrients systemic metabolism, mediating bidirectional communication with nervous system. suffers constant challenges to proteostasis machinery due its exposure dynamically changing microbial laden lumenal gut environment high secretory demand placed on multiple epithelial cell types accommodate physiology-especially goblet, enteroendocrine Paneth cells. In all cases, cells require active unfolded protein response (UPR) sustain their physiological function, main pathway that monitors adjusts function changes in environment. A specialised endoplasmic reticulum (ER) stress sensor uniquely expressed lining mucosal surfaces, termed inositol-requiring transmembrane kinase/endoribonuclease β, has specific roles homeostasis, mucus production microbiota. Chronic ER or genetic mutations affecting key UPR mediators contribute occurrence inflammatory bowel disease ulcerative colitis, addition colon cancer. Here, we review recent advances linking physiology disease. Therapeutic strategies alleviate enforce improve ageing diseases are also discussed.

Language: Английский