Nutrients,
Journal Year:
2024,
Volume and Issue:
16(24), P. 4365 - 4365
Published: Dec. 18, 2024
Background/Objectives:
Inflammatory
bowel
disease
(IBD)
is
a
chronic
condition
influenced
by
variety
of
factors,
including
genetics,
the
environment,
and
gut
microbiota.
The
incidence
IBD
increasing
globally.
Previous
studies
have
shown
that
interactions
between
diet
microbiota
influence
pathogenesis
treatment
IBD.
Proper
dietary
nutrition
oat
bran
regulates
inflammation,
which
essential
for
individual
health,
one
factors
in
reducing
inflammation
body
keeping
immune
system
functioning
properly,
plays
role
prevention
diseases.
However,
mechanism
action
whether
will
alleviate
modulating
intestinal
flora
metabolites
remains
unknown.
Methods:
Therefore,
this
study,
we
used
mouse
model
dextran
sulfate
sodium
(DSS)
colitis
to
analyze
composition
microbiota,
short-chain
fatty
acid
content,
expression
relevant
genes.
Results:
results
showed
diets
supplemented
with
improved
barrier
parameters,
decreased
levels
inflammatory
modulated
increased
content
acids.
Conclusions:
This
study
provides
strong
evidence
interventions
oats
or
may
potential
applications
clinical
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
unknown, P. 139810 - 139810
Published: Jan. 1, 2025
The
study
was
conducted
to
explore
the
relationship
between
arabinoxylan
(AX)
structure
and
microbial
fermentation
characteristics,
reveal
molecular
mechanism
of
AX
on
regulating
immune
function
host.
Results
indicated
that
group
wheat
bran
showed
greater
activity
feruloyl
esterase,
production
short
chain
fatty
acids
ferulic
acid
compared
with
blank
(P
<
0.05).
increased
sIgA
concentration
protein
expression
TLR4
NF-κB
(p65),
but
decreased
mRNA
pro-inflammatory
cytokines
in
ileum
weaned
pig
model,
leading
reduced
diarrhea
an
abundance
Bifidobacterium
pseudocatenulatum,
butyric
ileal
digesta
pigs
In
a
LPS-treated
mouse
combination
IL-10
IL-6
gene
(p65)
jejunum.
summary,
is
fermented
by
gut
microbiota
produce
acid,
as
well
which
improved
host
immunity
promoting
relative
pseudocatenulatum
suppressing
activation
TLR4/NF-κB
signaling.
Polyphenols
(PFs)
are
compounds
found
in
fruits
and
vegetables,
known
for
their
health-related
benefits,
mainly
including
antioxidant,
antiinflammatory,
anticancer
properties.
However,
efficacy
is
limited
by
poor
bioavailability
due
to
issues
like
low
solubility,
rapid
metabolism,
extensive
excretion.
Thus,
research
has
focused
on
improving
delivery
systems,
such
as,
example,
nanoparticles,
hydrogels,
cocrystals,
or
conjugation
with
carrier
molecules,
which
may
protect
PFs
from
degradation,
improve
and/or
facilitate
targeted
cancer
cells.
promising
modulating
cancer-related
pathways
cell
proliferation
death,
metastatic
invasion,
though
translation
patients
hindered
complex
mechanisms.
This
review
analyzes
factors
that
affect
PF
bioavailability,
evidences
of
vivo
effects
animal
models
mechanisms,
results
clinical
trials,
strategies
enhance
bioavailability.
The
idea
need
directly
interact
the
challenged.
Future
aims
optimize
combine
standard
treatments,
explore
epigenetic
effects,
modulation
tumor
microenvironment,
interactions
gut
microbiota.
Advances
personalized
medicine
structural
modifications
stability
absorption
could
further
potential.
Despite
challenges,
remain
a
avenue
complementary
oncotherapy
solutions.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: April 9, 2025
Colorectal
cancer
(CRC)
is
a
major
global
health
issue,
with
rising
incidence
and
mortality
rates.
Dietary
factors,
especially
whole
grains
consumption,
are
critical
in
determining
CRC
risk.
Understanding
deaths
disability-adjusted
life
years
(DALYs)
related
to
low
diets
important
for
prevention.
The
purpose
of
the
study
investigate
temporal
geographic
trends
DALYs
attributable
diet
at
global,
regional,
national
levels
from
1990
2021.
data
on
burden
2021
were
extracted
Global
Burden
Diseases
(GBD)
database.
We
described
across
various
years,
genders,
age
groups
(5-year
25
94
95+
years),
different
Socio-demographic
Index
(SDI)
regions
countries.
To
illustrate
CRC,
we
calculated
estimated
annual
percentage
change
(EAPC)
From
2021,
number
increased
101,813
(95%
UI:
42,588
151,170)
186,257
76,127
284,803),
representing
82.94%
growth.
Similarly,
2,540,867
1,050,794
3,754,416)
4,327,219
1,754,865
6,578,232),
70.30%
However,
both
age-standardized
rate
(ASMR)
DALY
(ASDR)
exhibited
decline,
an
EAPC
-0.82
CI:
-0.85
-0.78)
-
0.84
-0.87
-0.81),
respectively.
disease
heavier
high
SDI
high-middle
regions.
between
only
region
where
ASMR
ASDR
was
low-middle
SDI,
while
all
other
regions,
they
showed
declining
trend.
In
East
Asia
had
highest
regional
level,
followed
by
Western
Europe
High-income
North
America.
Additionally,
greater
among
males
elderly.
Between
rose
102.13%
63.20%
females.
Generally,
age-specific
tend
increase
age.
demonstrates
nonlinear
"S"-shaped
correlation
grains.
negatively
associated
(R
=
-0.402,
p
<
0.001),
reaching
approximately
0.51
lowest
0.85.
similar
pattern.
Despite
decline
globally,
absolute
cases
continues
increase,
particularly
notable
observed
High-middle
High
as
well
elderly
population.
It
imperative
intensify
efforts
prevention
education,
specifically
targeting
these
high-risk
raise
public
awareness
consumption
Furthermore,
screening
initiatives
should
be
intensified
demographics
address
elevated
risk
due
insufficient
consumption.
Foods,
Journal Year:
2025,
Volume and Issue:
14(7), P. 1114 - 1114
Published: March 24, 2025
Phenolic
compounds
in
cereals,
known
for
their
biological
activities,
are
primarily
found
a
bound
state
within
the
bran.
Their
changes
during
digestion
linked
to
physiological
activities.
In
this
study,
dynamic
and
fermentation
characteristics
of
barley
phenolics
(BBPs)
were
investigated
through
an
vitro
rat
gastrointestinal
colonic
fermentation.
UPLC-HRMS
revealed
that
release
rate
BBPs
was
significantly
higher
than
gastric
(0.13%)
intestinal
(0.43%),
reaching
5.02%.
After
48
h
fermentation,
gallic
acid
ferulic
accounted
35.05%
27.84%
total
released
phenolic
acids,
respectively.
Confocal
microscopy
confirmed
predominantly
colon.
Additionally,
increased
content
acetate
compared
control
samples,
correlating
with
decrease
pH
value.
16S
rRNA
sequencing
further
modulatory
effects
on
microbiota
structure:
enhanced
Chao1
Shannon
indices
microbiota.
Notably,
inhibited
growth
potentially
harmful
bacteria
such
as
Proteobacteria
Enterobacteriaceae
while
promoting
proliferation
beneficial
Akkermansia
Bifidobacteriaceae,
thereby
modulating
structure
gut
microbial
community.
These
findings
suggested
may
promote
health
prebiotic
activity
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(14), P. 2373 - 2373
Published: July 22, 2024
Existing
research
shows
an
inconsistent
correlation
between
whole-grain
intake
and
obesity
risk,
with
limited
study
on
the
dose–response
relationship.
Here,
we
aimed
to
examine
this
association
relationship
among
U.S.
adults
who
participated
in
a
NHANES
(2003–2018).
The
of
whole
grain
was
collected
calculated
from
two
rounds
24
h
dietary
recall.
Obesity
categorized
based
body
mass
index
(BMI)
waist
circumference
(WC).
Weighted
multivariable
logistic
regression
models
were
used
calculate
odds
according
intake,
modeled
by
restricted
cubic
spline
regression.
Among
27,862
participants,
38.3%
had
general
obesity,
while
58.3%
abdominal
obesity.
After
multivariate
adjustment
potential
confounders,
participants
highest
quintile
lower
prevalence
(OR
0.79;
95%
CI
0.72–0.88)
0.80;
0.73–0.89)
compared
those
lowest
category.
Spline
showed
inversely
linear
In
conclusion,
higher
associated
both
abdominal.
Our
findings
highlight
importance
increasing
prevent
manage
