Effects of steam explosion on the structural, physicochemical, and functional characteristics of dietary fiber in sorghum grains

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117522 - 117522

Published: Feb. 1, 2025

Language: Английский

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Comprehensive evaluation on phenolic derivatives and antioxidant activities of diverse yellow maize varieties

Food Chemistry, Journal Year: 2024, Volume and Issue: 464, P. 141602 - 141602

Published: Oct. 9, 2024

Language: Английский

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Dietary polyphenols alleviate alcoholic liver injury: potential mechanisms, product development status, and future research directions

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

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“Cupuaçu” (Theobroma grandiflorum): A brief review on chemical and technological potential of this Amazonian fruit

Food Chemistry Advances, Journal Year: 2024, Volume and Issue: 5, P. 100747 - 100747

Published: June 15, 2024

Language: Английский

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Ferulic acid mediates microbial fermentation of arabinoxylan to enhance host immunity by suppressing TLR4/NF-κB signaling

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139810 - 139810

Published: Jan. 1, 2025

The study was conducted to explore the relationship between arabinoxylan (AX) structure and microbial fermentation characteristics, reveal molecular mechanism of AX on regulating immune function host. Results indicated that group wheat bran showed greater activity feruloyl esterase, production short chain fatty acids ferulic acid compared with blank (P < 0.05). increased sIgA concentration protein expression TLR4 NF-κB (p65), but decreased mRNA pro-inflammatory cytokines in ileum weaned pig model, leading reduced diarrhea an abundance Bifidobacterium pseudocatenulatum, butyric ileal digesta pigs In a LPS-treated mouse combination IL-10 IL-6 gene (p65) jejunum. summary, is fermented by gut microbiota produce acid, as well which improved host immunity promoting relative pseudocatenulatum suppressing activation TLR4/NF-κB signaling.

Language: Английский

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Changes of Barley Bound Phenolics and Their Characteristics During Simulated Gastrointestinal Digestion and Colonic Fermentation In Vitro

Foods, Journal Year: 2025, Volume and Issue: 14(7), P. 1114 - 1114

Published: March 24, 2025

Phenolic compounds in cereals, known for their biological activities, are primarily found a bound state within the bran. Their changes during digestion linked to physiological activities. In this study, dynamic and fermentation characteristics of barley phenolics (BBPs) were investigated through an vitro rat gastrointestinal colonic fermentation. UPLC-HRMS revealed that release rate BBPs was significantly higher than gastric (0.13%) intestinal (0.43%), reaching 5.02%. After 48 h fermentation, gallic acid ferulic accounted 35.05% 27.84% total released phenolic acids, respectively. Confocal microscopy confirmed predominantly colon. Additionally, increased content acetate compared control samples, correlating with decrease pH value. 16S rRNA sequencing further modulatory effects on microbiota structure: enhanced Chao1 Shannon indices microbiota. Notably, inhibited growth potentially harmful bacteria such as Proteobacteria Enterobacteriaceae while promoting proliferation beneficial Akkermansia Bifidobacteriaceae, thereby modulating structure gut microbial community. These findings suggested may promote health prebiotic activity

Language: Английский

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Polyphenols: Potential Applications in Cancer Therapy

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Polyphenols (PFs) are compounds found in fruits and vegetables, known for their health-related benefits, mainly including antioxidant, antiinflammatory, anticancer properties. However, efficacy is limited by poor bioavailability due to issues like low solubility, rapid metabolism, extensive excretion. Thus, research has focused on improving delivery systems, such as, example, nanoparticles, hydrogels, cocrystals, or conjugation with carrier molecules, which may protect PFs from degradation, improve and/or facilitate targeted cancer cells. promising modulating cancer-related pathways cell proliferation death, metastatic invasion, though translation patients hindered complex mechanisms. This review analyzes factors that affect PF bioavailability, evidences of vivo effects animal models mechanisms, results clinical trials, strategies enhance bioavailability. The idea need directly interact the challenged. Future aims optimize combine standard treatments, explore epigenetic effects, modulation tumor microenvironment, interactions gut microbiota. Advances personalized medicine structural modifications stability absorption could further potential. Despite challenges, remain a avenue complementary oncotherapy solutions.

Language: Английский

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The burden of colorectal cancer attributable to diet low in whole grains from 1990 to 2021: a global, regional and national analysis

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 9, 2025

Colorectal cancer (CRC) is a major global health issue, with rising incidence and mortality rates. Dietary factors, especially whole grains consumption, are critical in determining CRC risk. Understanding deaths disability-adjusted life years (DALYs) related to low diets important for prevention. The purpose of the study investigate temporal geographic trends DALYs attributable diet at global, regional, national levels from 1990 2021. data on burden 2021 were extracted Global Burden Diseases (GBD) database. We described across various years, genders, age groups (5-year 25 94 95+ years), different Socio-demographic Index (SDI) regions countries. To illustrate CRC, we calculated estimated annual percentage change (EAPC) From 2021, number increased 101,813 (95% UI: 42,588 151,170) 186,257 76,127 284,803), representing 82.94% growth. Similarly, 2,540,867 1,050,794 3,754,416) 4,327,219 1,754,865 6,578,232), 70.30% However, both age-standardized rate (ASMR) DALY (ASDR) exhibited decline, an EAPC -0.82 CI: -0.85 -0.78) - 0.84 -0.87 -0.81), respectively. disease heavier high SDI high-middle regions. between only region where ASMR ASDR was low-middle SDI, while all other regions, they showed declining trend. In East Asia had highest regional level, followed by Western Europe High-income North America. Additionally, greater among males elderly. Between rose 102.13% 63.20% females. Generally, age-specific tend increase age. demonstrates nonlinear "S"-shaped correlation grains. negatively associated (R = -0.402, p < 0.001), reaching approximately 0.51 lowest 0.85. similar pattern. Despite decline globally, absolute cases continues increase, particularly notable observed High-middle High as well elderly population. It imperative intensify efforts prevention education, specifically targeting these high-risk raise public awareness consumption Furthermore, screening initiatives should be intensified demographics address elevated risk due insufficient consumption.

Language: Английский

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Research on the Anti-aging Activity of Different Mulberry Leaf Products: Based on Mulberry Leaf Powder and Mulberry Leaf Extract.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106785 - 106785

Published: May 1, 2025

Language: Английский

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Effect of Raspberry (Rubus indeaus L.) Juice Fermented by Limosilactobacillus fermentum FUA033 on the Human Gut Microbiota Cultured In Vitro: A Multi-Omics Approach

Foods, Journal Year: 2025, Volume and Issue: 14(10), P. 1796 - 1796

Published: May 18, 2025

The gut microbiota plays important functions in human health and influences immune responses, metabolic processes, several physiological activities. modulation of the through dietary interventions has emerged as a promising approach, leading to significant interest development functional foods that provide benefits. In this context, our study investigated effects raspberry juice fermented by Limosilactobacillus fermentum FUA033 on structure metabolism microbiota. We performed 16S rRNA gene sequencing nontargeted metabolomics analyses evaluate changes microbial composition metabolite profiles resulting from fermentation. Our findings revealed considerably increased diversity promoted abundance beneficial genera. Fermentation substantially production short-chain fatty acids, such acetate butyrate, which 30.09 ± 5.23 mmol/L 43.07 3.31 mmol/L, 7.72 1.72 15.01 1.26 respectively. Metabolomic also showed enhancements amino acid pathways, particularly those involving tyrosine, arginine, proline. These results highlight potential food improve functions.

Language: Английский

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