Relationship of oxidative balance score to gallstone prevalence and gallbladder surgery in American adults: evidence from NHANES 2017-2020 DOI Creative Commons

Shouxin Wei,

Sijia Yu,

Zhengwen Xu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Gallstones represent a common gastrointestinal disorder, affecting approximately 10-20% of the global population. Oxidative stress plays pivotal role in pathogenesis gallstones; however, there remains lack effective clinical indicators to predict their formation. This study addresses this gap by investigating relationship between oxidative balance score (OBS) and incidence gallstones gallbladder surgery, utilizing data from National Health Nutrition Examination Survey (NHANES) 2017 2020. Methods: investigated association OBS occurrence surgery analyzing NHANES for period 2017–2020, adjusting potential confounders such as age, sex, race, comorbidities. Various statistical analyses were applied, including multivariate logistic regression, subgroup analyses, smoothed curve-fitting models.Results: The results revealed significant negative correlation risks both with each one-unit increase associated 2.6% reduction gallstone risk (OR=0.974, 95% CI: 0.958-0.990) 3.3% (OR=0.967, 0.950-0.983). Subgroup confirmed consistency these associations across various demographic health-related factors. Furthermore, dose-response was observed higher reduced surgery.Conclusions: demonstrates that is lower rates offering new insights into link levels formation well surgical intervention. findings underscore valuable tool identifying at-risk populations informing personalized prevention strategies disease.

Language: Английский

Relationship of oxidative balance score to gallstone prevalence and gallbladder surgery in American adults: evidence from NHANES 2017-2020 DOI Creative Commons

Shouxin Wei,

Sijia Yu,

Zhengwen Xu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Gallstones represent a common gastrointestinal disorder, affecting approximately 10-20% of the global population. Oxidative stress plays pivotal role in pathogenesis gallstones; however, there remains lack effective clinical indicators to predict their formation. This study addresses this gap by investigating relationship between oxidative balance score (OBS) and incidence gallstones gallbladder surgery, utilizing data from National Health Nutrition Examination Survey (NHANES) 2017 2020. Methods: investigated association OBS occurrence surgery analyzing NHANES for period 2017–2020, adjusting potential confounders such as age, sex, race, comorbidities. Various statistical analyses were applied, including multivariate logistic regression, subgroup analyses, smoothed curve-fitting models.Results: The results revealed significant negative correlation risks both with each one-unit increase associated 2.6% reduction gallstone risk (OR=0.974, 95% CI: 0.958-0.990) 3.3% (OR=0.967, 0.950-0.983). Subgroup confirmed consistency these associations across various demographic health-related factors. Furthermore, dose-response was observed higher reduced surgery.Conclusions: demonstrates that is lower rates offering new insights into link levels formation well surgical intervention. findings underscore valuable tool identifying at-risk populations informing personalized prevention strategies disease.

Language: Английский

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