The association between frailty index and abdominal aortic calcification in the middle-aged and older US adults: NHANES 2013–2014 DOI Creative Commons
Zhengjun Zhang,

Peng Wu,

Shaobin Yang

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: May 7, 2025

Background Abdominal aortic calcification (AAC) is one of the earliest observed forms atherosclerotic and crucial for early cardiovascular risk prediction. Frailty, a global clinical public health challenge, associated with increased risks mortality, functional decline, loss independence. However, relationship between Frailty Index (FI) AAC among middle-aged older adults has yet to be explored. Methods This study analyzed data from 2013 2014 National Health Nutrition Examination Survey (NHANES) cohort, focusing on individuals aged ≥ 40 years. The FI was calculated using 49-item model assess frailty status participants were stratified into three groups: non-frail (FI ≤ 0.15), pre-frail (0.15 < 0.25), frail > 0.25). measured by dual-energy X-ray absorptiometry quantified Kauppila scores. Severe defined as an score 6. investigated multivariable logistic regression, sensitivity analyses, smoothing curve fitting. Subgroup analyses interaction tests conducted stability this association across different populations. Results A total 2,572 enrolled in study. Following adjustment potential confounders, exhibited statistically significant positive both (β = 2.64, 95%CI 1.20–4.08) (OR 6.36, 1.48–27.41). Similar trends ( P trend 0.05) when categorical variable. Smooth fitting subgroup analysis used investigate baseline Z-score AAC. Interestingly, we found that linearly related occurrence severe AAC, while it nonlinearly score. FI-Z positively likelihood before breakpoint K 0.78), but not after breakpoint. stable subgroups (all 0.05). Conclusion Our indicated correlation may serve biomarker subclinical atherosclerosis detection US adults.

Language: Английский

Adherence to combined healthy lifestyle and odds of metabolic syndrome in Iranian adults: the PERSIAN Dena cohort study DOI Creative Commons
Mohammad-Reza Jowshan,

Abdollah Pourjavid,

Farshad Amirkhizi

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 12, 2025

The relationship between lifestyle choices and health outcomes has received significant scholarly attention. Research indicates that factors such as obesity, insufficient physical activity, tobacco use, poor dietary habits may elevate the odds of developing metabolic disorders. This study aimed to investigate association combined healthy score (HLS) syndrome (MetS) its associated components in a population apparently adults. cross-sectional utilized data from Dena PERSIAN cohort, which comprised 2,971 Participants' HLS were evaluated using validated questionnaires assessed body mass index (BMI), activity level (PAL), smoking status, quality. evaluation nutritional quality was conducted most recent version Healthy Eating Index (HEI), known HEI-2020. measured on scale ranging zero, indicating an unhealthy lifestyle, four, representing healthiest lifestyle. Individuals with highest had 81% lower having MetS compared those lowest (OR: 0.19; 95% CI: 0.11–0.33). Higher scores significantly decreased abdominal adiposity 0.11; 0.07–0.18), abnormal glucose homeostasis 0.55; 0.35–0.86), elevated serum triglycerides 0.41; 0.26–0.67), low high-density lipoprotein cholesterol (HDL-C) levels 0.39; 0.24–0.65) after adjusting for sex, age, education level, marital status (P < 0.05). findings indicated adherence among Iranian

Language: Английский

Citations

1
Association of ultra-processed foods with phenotypic age acceleration in US adults: a mediation analysis of body mass index in the NHANES DOI Creative Commons
Weiliang Kong, Yilian Xie,

Mengyuan Cen

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 24, 2025

Background The rising intake of ultra-processed foods (UPFs) has been linked to adverse health outcomes, yet its impact on aging acceleration remains unclear. Objective This study aimed examine the association between percentage total daily calories (%Kcal) and grams (%Gram) from UPFs phenotypic age (PhenoAgeAccel). Methods Data 12,079 adults in NHANES 2005–2010 cycles were analyzed. relationship PhenoAgeAccel was assessed using multivariable linear regression restricted cubic splines, with adjustments for relevant covariates. mediating role body mass index (BMI) also explored. Results A significant positive observed PhenoAgeAccel, highest quartile showing an increase 0.60 (95% CI: 0.15, 1.05; p trend = 0.039), but no found PhenoAgeAccel. Mediation analysis indicated that BMI mediated 27.5% Sensitivity analyses confirmed robustness results. Conclusion Higher is positively associated playing a role.

Language: Английский

Citations

0
Healthy dietary patterns, biological aging, and kidney stones: evidence from NHANES 2007–2018 DOI Creative Commons
Chengcheng Wei, Qian Yang, Jing He

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 25, 2025

Background This study aims to investigate the comprehensive association between healthy dietary patterns, biological aging, and kidney stones in a large population-based cohort. Methods We analyzed data from 6 cycles of NHANES surveys 2007 2018 included total 26,755 participants. The was examined using logistic regression, restricted cubic splines, mediation model. Machine learning with Shapley Additive Explanations (SHAP) used determine relative importance factors. Sensitivity analysis conducted validate stability results. Results A higher score significantly associated reduced risk stone prevalence, as indicated by Alternative Healthy Eating Index (AHEI) (OR = 0.76, 95% CI 0.69–0.84), Dietary Approaches Stop Hypertension (DASHI) 0.67, 0.58–0.77), 2020 (HEI-2020) 0.80, 0.72–0.89), Mediterranean Diet (MEDI) 0.81, 0.73–0.89). Conversely, aging indicators were an increased stones, including following: Klemera-Doubal Method Age (KDMAge) 2.40, 1.70–3.37) Phenotypic (PhenoAge) 2.36, 1.75–3.19). Mediation analyses suggested that mediated relationship patterns stones. SHAP revealed specific components this association. sensitivity largely consistent primary analyses. Conclusion These findings provide valuable insights into complex interplay stone. Promoting may be effective strategy for prevention, potentially through modulation processes.

Language: Английский

Citations

0
The association between frailty index and abdominal aortic calcification in the middle-aged and older US adults: NHANES 2013–2014 DOI Creative Commons
Zhengjun Zhang,

Peng Wu,

Shaobin Yang

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: May 7, 2025

Background Abdominal aortic calcification (AAC) is one of the earliest observed forms atherosclerotic and crucial for early cardiovascular risk prediction. Frailty, a global clinical public health challenge, associated with increased risks mortality, functional decline, loss independence. However, relationship between Frailty Index (FI) AAC among middle-aged older adults has yet to be explored. Methods This study analyzed data from 2013 2014 National Health Nutrition Examination Survey (NHANES) cohort, focusing on individuals aged ≥ 40 years. The FI was calculated using 49-item model assess frailty status participants were stratified into three groups: non-frail (FI ≤ 0.15), pre-frail (0.15 &lt; 0.25), frail &gt; 0.25). measured by dual-energy X-ray absorptiometry quantified Kauppila scores. Severe defined as an score 6. investigated multivariable logistic regression, sensitivity analyses, smoothing curve fitting. Subgroup analyses interaction tests conducted stability this association across different populations. Results A total 2,572 enrolled in study. Following adjustment potential confounders, exhibited statistically significant positive both (β = 2.64, 95%CI 1.20–4.08) (OR 6.36, 1.48–27.41). Similar trends ( P trend 0.05) when categorical variable. Smooth fitting subgroup analysis used investigate baseline Z-score AAC. Interestingly, we found that linearly related occurrence severe AAC, while it nonlinearly score. FI-Z positively likelihood before breakpoint K 0.78), but not after breakpoint. stable subgroups (all 0.05). Conclusion Our indicated correlation may serve biomarker subclinical atherosclerosis detection US adults.

Language: Английский

Citations

0