Catalase-assembled nanoparticles for PA/CT dual-modality imaging and repair of acute alcoholic gastritis

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 169, P. 214181 - 214181

Published: Jan. 9, 2025

Language: Английский

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Effects of short term dietary zinc deficiency and zinc supplementation on nitro-oxidative stress in testes of Wistar rats

BioMetals, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Language: Английский

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Gene Editing: An Effective Tool for the Future Treatment of Kidney Disease

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 4001 - 4018

Published: March 1, 2025

Gene editing technology involves modifying target genes to alter genetic traits and generate new phenotypes. Beginning with zinc-finger nucleases (ZFN) transcription activator-like effector (TALEN), the field has evolved through advent of clustered regularly interspaced short palindromic repeats CRISPR-associated protein (CRISPR-Cas) systems, more recently base editors (BE) prime (PE). These innovations have provided deep insights into molecular mechanisms complex biological processes paved way for novel therapeutic strategies a range diseases. is now being applied in treatment both acquired kidney diseases, as well transplantation correction mutations. This review explores current applications mainstream gene technologies biology, particular emphasis on their roles disease research of. It also addresses limitations challenges associated these technologies, while offering perspectives future potential this field.

Language: Английский

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Zinc sulphate attenuates metabolic dysfunctions induced by olanzapine via the reduction of insulin resistance, hepatic oxidative stress, and inflammation in albino rats

BMC Pharmacology and Toxicology, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 14, 2025

Abstract Olanzapine, an atypical antipsychotic drug, is used to treat psychological diseases. However, it’s use carries common side effects. Those include weight gain, dyslipidemia, elevated glucose levels, and disrupted oxidative balance. We aimed test the effect of zinc coadministration lessen metabolic disturbances, inflammation stress in a rat model. Four treatment groups ( n = 6) were involved this investigation. Group 1 was control group (received no intervention). 2 received olanzapine (10 mg/kg, p.o.; daily) for six weeks, whereas Groups 3 4 50 mg/kg 100 sulphate (ZnSO ,p.o.; respectively, addition daily). Following completion, showed increased levels markers (GSSG, MDA, NO) impaired antioxidant (CAT, SOD, GSH). Further, strong positive correlation between insulin resistance index (HOMA-IR) IL-6, TNF-α, MDA liver. Insulin possible manifestation burden widespread inflammatory environment. In 4, however, ZnSO recovered each these dose-dependent manner. Improvements also noted other homeostatic markers, such as taurine, coenzyme Q10, ascorbic acid, vitamin E. Remarkably, both combination groups, there significant improvement all indicators dyslipidemia (triglycerides, total cholesterol) index. The biochemical study histological assessment liver slices agreed with results. Thus, results clearly suggest that Zinc supplementation can significantly improve stress, inflammation, perturbation (dyslipidemia resistance), injury caused by Albino rats.

Language: Английский

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Anti-inflammatory effects of 64Zn-aspartate is accompanied by cognitive improvements in rats with Aβ1-40-induced alzheimer disease

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 24, 2025

Language: Английский

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High-fat intake induces gut microbiota disorders, inflammatory responses and oxidative stress in Nyctereutes procyonoides

Animal Diseases, Journal Year: 2024, Volume and Issue: 4(1)

Published: Aug. 6, 2024

Abstract The Nyctereutes procyonoides is highly regarded in the farming and leather industries because of high value its fur, which renders artificial feeding a crucial aspect. However, high-fat diets have always been associated with variety digestive disorders. This study aimed to investigate impact on gut microbiota mechanisms damage . 16S rRNA sequencing demonstrated that caused diarrhea intestinal through alterations microbiota: decrease abundance Firmicutes, an increase Proteobacteria Actinobacteria , Enterococcaceae Escherichia coli-Shigella Clostridium Lactobacillus Subsequently, changes metabolic pathways, such as amino fatty acid were identified by KEGG COG enrichment analysis, TLR4/NF-κB/NLRP3 inflammatory signaling pathway was shown be activated diets. In addition, lead accumulation ROS MDA reduce activity antioxidant enzymes GSH-PX SOD. Correspondingly, levels proinflammatory cytokines (IL-6, IL-1β TNF-α) significantly increased, apoptosis necrosis pathways colonic cells detected, causing dramatic expression tight junction proteins (Occludin, E-cadherin, ZO-1 ZO-2). conclusion, altered structure community led colon damage. provides new insights into health Graphical

Language: Английский

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Metal-Dependent Cell Death in Renal Fibrosis: Now and in the Future

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13279 - 13279

Published: Dec. 11, 2024

Renal fibrosis is a common final pathway underlying nearly almost all progressive kidney diseases. Metal ions are essential trace elements in organisms and involved important physiological activities. However, aberrations intracellular metal ion metabolism may disrupt homeostasis, causing cell death increasing susceptibility to various Accumulating evidence suggests complex association between metal-dependent renal fibrosis. In this article, we provide comprehensive overview of the specific molecular mechanisms their crosstalk, up-to-date supporting role fibrosis, therapeutic targeting strategies, research needs, aiming offer rationale for future clinical treatment

Language: Английский

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