Mediterranean Diet and Lifestyle in Persons with Mild to Moderate Alzheimer’s Disease

Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3421 - 3421

Published: Oct. 9, 2024

Due to the continuous aging of population and consequent increase in dementia, focus on its prevention is growing importance for public health. Since effective pharmacological treatments are not yet available, other determinants cognitive decline have become fundamental. Several studies indicated that Mediterranean diet (MedDiet) associated with reduced incident but few been conducted persons already diagnosed Alzheimer’s disease (AD). We age-matched 73 patients mild–moderate AD controls (mean age whole group = 76.5 ± 6.5; 67.5% women). The cases had a significantly lower adherence MedDiet physical activity vs. controls, where only one participant (1.4%) high among compared 5.5% while 52.5% moderate 82.2% controls. In multivariate analysis, presence was Other factors examined (gender, age, level, multimorbidity, polypharmacy) were MedDiet. Thus, low very activity. Public health strategies aimed at promoting older people should be priority.

Language: Английский

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The Role of Genetic, Environmental, and Dietary Factors in Alzheimer’s Disease: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1222 - 1222

Published: Jan. 30, 2025

Alzheimer’s disease (AD) is one of the most common and severe forms dementia neurodegenerative disease. As life expectancy increases in line with developments medicine, elderly population projected to increase next few decades; therefore, an prevalence some diseases, such as AD, also expected. a result, until radical treatment becomes available, AD expected be more frequently recorded top causes death worldwide. Given current lack cure for only treatments available being ones that alleviate major symptoms, identification contributing factors influence incidence crucial. In this context, genetic and/or epigenetic factors, mainly environmental, disease-related, dietary, or combinations/interactions these are assessed. review, we conducted literature search focusing on environmental air pollution, toxic elements, pesticides, infectious agents, well dietary including various diets, vitamin D deficiency, social (e.g., tobacco alcohol use), variables affected by both behavior gut microbiota. We evaluated studies beneficial effects antibiotics Mediterranean-DASH Intervention Neurodegenerative Delay (MIND) Mediterranean diets.

Language: Английский

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Coffee as a Source of Antioxidants and an Elixir of Youth

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 285 - 285

Published: Feb. 27, 2025

Coffee is more than a universally loved beverage; it complex matrix of bioactive compounds that contribute to its multifaceted health benefits. From role as potent source antioxidants potential anti-aging effects, coffee has proven be valuable component balanced diet. This paper highlights the extensive scientific evidence supporting coffee's ability combat oxidative stress, enhance cognitive function, and improve metabolic cardiovascular health. Additionally, in modulating key cellular pathways underscores positively influence aging longevity. manuscript emphasizes broader cultural, economic, historical significance, illustrating enduring relevance contemporary society. Despite minor discrepancies research findings, preponderance functional food with profound implications for healthspan aging. While promising, translating findings humans requires further clinical research.

Language: Английский

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Updating risk and protective factors for dementia in older adults

Nature Reviews Psychology, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Language: Английский

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Caffeine Inhibits Tau Aggregation and Destabilizes the Fibril Associated with Chronic Traumatic Encephalopathy: A REST2 and Conventional MD Simulations Study

Journal of Chemical Information and Modeling, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Chronic traumatic encephalopathy (CTE) is a unique tauopathy mostly diagnosed in contact sports athletes, such as those active American football, boxing, soccer, etc. The hyperphosphorylated fibrillar aggregates composed of self-assembled tau protein are the pathological hallmark CTE, and inhibiting aggregation or disassociating has been considered promising avenue to prevent treat CTE. Caffeine (CA) well-known psychostimulant can be found coffee, tea, soft drinks. In vitro experiments revealed that CA could effectively inhibit wild-type disassemble preformed fibrils. However, atomic effect underlying molecular mechanisms remain largely elusive. this study, we performed multitude replica exchange with solute tempering 2 (REST2) conventional dynamics (CMD) simulations 43.8 μs total on models without CA, including third fourth microtubule-binding repeats (R3-R4) monomer CTE-related R3-R4 protofibril fibril. results prominently β-sheet formation disrupt structure protofibril, inducing adopt loosely packed extended conformations. H-bonding π-π stacking interactions drove binding monomer, while hydrophobic made an extra contribution protofibril. Strikingly, stably bind cavity which might occupy space entering cofactor. What more, destabilized fibril played role reversing liquid-to-solid phase transition (LSPT) tau. Our study systematically uncovered atomic-level aggregation, offers theoretical foundation for design drugs

Language: Английский

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Sulforaphane suppresses Aβ accumulation and tau hyperphosphorylation in vascular cognitive impairment(VCI)

The Journal of Nutritional Biochemistry, Journal Year: 2024, Volume and Issue: unknown, P. 109803 - 109803

Published: Nov. 1, 2024

Language: Английский

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Effect of proanthocyanidins on cognitive improvement in thyroxin-induced aging mice

Food & Function, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

As the population ages, functional dietary supplements are increasingly used to reduce age-related diseases, especially in field of cognitive impairment. In this study, a thyroxine (Th)-induced aging model was established, and effect proanthocyanidins (Pc) on impairment mice evaluated based ability, neuroinflammation immune level. The results showed that Pc significantly reduced AchE activity compared Model group, improving learning deficits spatial memory aged (

Language: Английский

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