Therapeutic potential of flavonoids from traditional Chinese medicine in pancreatic cancer treatment

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 22, 2024

Pancreatic cancer (PC) is a highly aggressive malignancy with rising mortality rates globally. Its diagnosis often challenging due to its asymptomatic nature in the early stages. Consequently, most patients receive poor prognosis, low survival within 5 years, as disease typically detected at an advanced stage, complicating effective treatment. Flavonoids, especially those derived from traditional Chinese herbal medicines, have attracted considerable attention for their potent anti-PC properties. This review highlights therapeutic potential of these bioactive compounds, which modulate key biological pathways, making them promising candidates PC intervention. Their mechanisms action include regulation autophagy, apoptosis, cell growth, epithelial-mesenchymal transition, and oxidative stress, well enhancing chemotherapeutic sensitivity, exerting antiangiogenic effects, potentially boosting immunomodulatory responses. The demonstrated benefits natural compounds management spurred extensive academic interest. Beyond role anti-cancer agents, flavonoids may provide both preventive advantages PC, resonating core principles medicine prevention holistic

Language: Английский

Research summary, possible mechanisms and perspectives of gut microbiota changes causing precocious puberty

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 25, 2025

The increasing global incidence of precocious puberty, linked to environmental, metabolic, and genetic factors, necessitates innovative therapies beyond gonadotropin-releasing hormone (GnRH) analogs. Accumulating evidence implicates gut microbiota dysbiosis as a pivotal regulator pubertal timing via interactions with metabolism (e.g., estrogen reactivation β-glucuronidase), neuroendocrine pathways (nitric oxide signaling), immune-inflammatory responses. This review delineates taxonomic alterations in central puberty (CPP) obesity-related subtypes, including Streptococcus enrichment Alistipes depletion, alongside functional shifts microbial metabolite production. Mechanistic insights highlight microbiota-driven modulation the hypothalamic-pituitary-gonadal (HPG) axis, leptin/insulin dynamics, epigenetic regulation. Emerging interventions-probiotics, fecal transplantation (FMT), dietary modifications-demonstrate efficacy preclinical models early clinical studies for delaying onset restoring hormonal balance. Translational efforts validate these strategies are critical addressing psychosocial challenges posed by positioning novel therapeutic frontier pediatric endocrinology.

Language: Английский

Gut flora influences the hypothalamic-gonadal axis to regulate the pathogenesis of obesity-associated precocious puberty

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 21, 2024

The prevalence of obesity-associated precocious puberty is gradually increasing, but the relationship between gut flora and remains unclear.We analysed characteristics a clinical sample 30 girls aged 5–8 years using 16s rRNA sequencing. An obesity rat model transplantation were also constructed. Body weight, body length, abdominal girth, food intake, vulva opening time, gonadal index monitored. secretion levels estradiol (E2), total cholesterol (TC), follicle-stimulating hormone (FSH), luteinizing (LH), thyroglobulin (Tg) analyzed by ELISA. In addition, ovarian uterine development was observed HE staining. mRNA protein kisspeptin-1 (Kiss-1) gonadotropin-releasing.We found that relative abundance Dialister, Bacteroides, Bifidobacterium, Collinsella, Romboutsia may be associated with puberty. Obesity promotes development, patients regulated gene expression Kiss-1 GnRH, promoting hypothalamic-gonadal axis in rats. contrast, probiotic intervention slowed reduced secretion, attenuated activity. Gut promoted influencing axis, probiotics have therapeutic preventive role puberty, which Kiss-1/GnRH pathway. These findings provide some new strategies for treatment prevention girls.

Language: Английский