Extracellular vesicles: From large-scale production and engineering to clinical applications DOI Creative Commons

Yuxuan Wang,

Jiali Xiong,

Kun Ouyang

et al.

Journal of Tissue Engineering, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

Extracellular vesicles (EVs) have emerged as a promising strategy for treating wide spectrum of pathologies, they can deliver their cargo to recipient cells and regulate the signaling pathway these modulate fate. Despite great potential EVs in clinical applications, low yield challenges loading remain significant obstacles, hindering transition from experimental research practice. Therefore, promoting EV release enhancing cargo-loading are fields with substantial broad application prospects. In this review, we summarize applications EVs, methods technologies large-scale production, engineering, modification, well that must be addressed during development. We also discuss future perspectives exciting field facilitate its transformation bench reality.

Language: Английский

Multifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery DOI Creative Commons
Arzu Zeynep Karabay, Jaleh Barar, Yalda Hekmatshoar

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 394 - 394

Published: March 10, 2025

Most eukaryotic and prokaryotic cells have the potential to secrete a group of structures/membrane-bound organelles, collectively referred as extracellular vesicles (EVs), which offer several advantages producer/receiver cells. This review provides an overview EVs from plant sources with emphasis on their health-promoting possible use therapeutic agents. highlights essential biological effects plant-derived vesicles, including immune modulation, anticancer activities, protection against chemical toxicity pathogens, well anti-aging, anti-melanogenesis, anti-arthritic effects, along ongoing clinical studies. Evidence revealed that EVs’ contents exert beneficial properties through regulating important signaling pathways by transferring miRNAs other components. Taken all together, data proposed can be utilized nutritional compounds agents, such drug carriers. However, this emerging research area requires further in vitro/in vivo studies trials determine exact underlying mechanisms positive health treating various diseases.

Language: Английский

Citations

2
Carrier-free nanoparticles—new strategy of improving druggability of natural products DOI Creative Commons

Youyun Yao,

Zhenghu Xu, Hang Ding

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 14, 2025

There are abundant natural products resources and extensive clinical use experience in China. However, the active components of generally have problems such as poor water solubility low bioavailability, which limit their druggability. Carrier-free nanoparticles, nanocrystals, self-assembled extracellular vesicles derived from both animal plant sources, great application potential improving safety efficacy drugs due to simple flexible preparation methods, high drug loading capacity delivery efficiency, well long half-life blood circulation. It has been widely used biomedical fields anti-tumor, anti-bacterial, anti-inflammatory anti-oxidation. Therefore, based on that clinic, this review focuses advantages carrier-free nanoparticles delivering compounds, order improve process vivo draggability.

Language: Английский

Citations

1
Advances in Plant-Derived Extracellular Vesicle Extraction Methods and Pharmacological Effects DOI Creative Commons

Nuerbiye Nueraihemaiti,

Dilihuma Dilimulati,

Alhar Baishan

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 377 - 377

Published: April 6, 2025

Extracellular vesicles (EVs) are those with a double-membrane structure that contains proteins, lipids, nucleic acids, and other biologically active substances play an important role in cell–cell cell–environment communication. They have also become mechanism for exchanging cellular molecules. As many studies on EVs been conducted, plant-derived extracellular (PDEVs) started attracting attention. The biological activity stability of PDEVs closely related to the extraction separation methods, choosing method meets requirements is important. methods include ultracentrifugation, ultrafiltration, size-exclusion chromatography, etc. In recent years, it has found through research possess properties, such as anti-inflammatory, anti-cancer, anti-infective they show unique advantages therapeutic agents drug carriers. Therefore, we collected scientific literature derived from more than dozen fruits vegetables, summarized analyzed their extraction, separation, roles disease treatment, aiming provide reference inspiration in-depth study efficacy new drugs.

Language: Английский

Citations

0
Extracellular vesicles: From large-scale production and engineering to clinical applications DOI Creative Commons

Yuxuan Wang,

Jiali Xiong,

Kun Ouyang

et al.

Journal of Tissue Engineering, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

Extracellular vesicles (EVs) have emerged as a promising strategy for treating wide spectrum of pathologies, they can deliver their cargo to recipient cells and regulate the signaling pathway these modulate fate. Despite great potential EVs in clinical applications, low yield challenges loading remain significant obstacles, hindering transition from experimental research practice. Therefore, promoting EV release enhancing cargo-loading are fields with substantial broad application prospects. In this review, we summarize applications EVs, methods technologies large-scale production, engineering, modification, well that must be addressed during development. We also discuss future perspectives exciting field facilitate its transformation bench reality.

Language: Английский

Citations

0