Inflammatory parameters mediates the relationship between dietary index for gut microbiota and frailty in middle-aged and older adults in the United States: findings from a large-scale population-based study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 16, 2025

Frailty is a prevalent geriatric syndrome marked by diminished physiological reserves and heightened vulnerability to stressors, leading adverse health outcomes imposing significant economic burdens on healthcare systems. This study investigates the relationship between Dietary Index for Gut Microbiota (DI-GM) risk of frailty in middle-aged older adults, using data from National Health Nutrition Examination Survey (NHANES) collected 2007 2018. Weighted logistic regression, subgroup analysis, restricted cubic splines (RCS) were performed evaluate DI-GM risk. Additionally, mediation analysis was conducted investigate influence relevant inflammatory parameters complete blood count, including leukocyte neutrophil lymphocyte ratio (NLR), systemic response index (SIRI), elucidate how may onset progression frailty. In this cross-sectional 8,695 participants with mean age 65.56 years, 3,173 individuals classified as frail. After adjusting all covariates, inverse observed Quartile revealed that highest quartile had significantly lower odds compared those lowest (OR: 0.80, 95% CI: 0.65-0.99, p = 0.04). Trend analyses across models demonstrated consistent higher quartiles (p < 0.0001 crude model; 0.001 Model 1; 0.04 2). Subgroup confirmed stability impact various subgroups. RCS showed decreased linearly increasing levels. Mediation indicated effects NLR, SIRI, proportions 5.7, 7.9, 4.4, 5.5%, respectively (all 0.001). The levels are inversely associated frailty, part association mediated parameters.

Language: Английский

Association between dietary index for gut microbiota and female infertility: a cross-sectional NHANES 2013–2020

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 23, 2025

Background The relationship between the gut microbiota and infertility has garnered increasing attention. However, associations dietary index for (DI-GM), an indicator of microbial diversity, remain insufficiently explored. Methods We analyzed data from 3,058 participants in NHANES 2013–2020 cycles, employing weighted generalized linear models smooth curve analyses to examine their associations. Mediation analysis was conducted assess role body mass (BMI). Results After adjusting confounding factors, a higher DI-GM score significantly associated with lower prevalence (OR = 0.89, 95% CI 0.81–0.98, p 0.029). Compared individuals 0–3, those ≥6 presented 0.64, 0.43–0.96, 0.039). BMI mediated 5.98% association infertility. Conclusion A is Future studies should employ longitudinal designs validate these findings.

Language: Английский

Association between the dietary index for gut microbiota and female infertility: a cross-sectional study of NHANES 2013–2018

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 28, 2025

Background Infertility poses a substantial societal and economic burden; however, current preventive strategies are limited. Recently, the relationship between gut microbiota infertility has garnered increasing attention. The dietary index for (DI-GM) is new that reflects diversity of microbiota. However, its association with female remains unclear. Methods This cross-sectional study included 3,053 women aged 18–45 years from National Health Nutrition Examination Survey (NHANES) database 2013 2018. was defined based on responses to questionnaire reproductive health. DI-GM score calculated by averaging intake two 24-h recall interviews. Weighted multivariable logistic regression, restricted cubic splines (RCS), subgroup analyses were used investigate infertility. Results Based self-reported data, 370 participants (12.12%) classified as infertile. A higher proportion lower scores experienced Multivariable regression analysis indicated negative risk infertility, regardless whether independent variable analyzed continuous or in quartiles fully adjusted model (Model 3, variable: OR = 0.89, 95% confidence interval (CI): 0.80–0.98, p 0.025; Q4 vs. Q1: 0.63, CI 0.42–0.94, 0.032, trend 0.013). RCS curves demonstrated non-linear risk. Subsequent corroborated robustness these findings. Conclusion These findings suggest females, associated

Language: Английский