Recent Advances in Deoxygenative Thioether Synthesis Using Oxygenated Sulfur Surrogates

Synthesis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract Thioethers (sulfides) play a crucial role in therapeutics, diagnostics, and functional materials. Traditionally, their synthesis involved the use of thiols or derivatives, which are associated with unpleasant odors potential health risks. Recently, significant research has focused on employing oxygenated sulfur compounds, such as sulfinates, sulfonyl oxyacids, sulfoxides, thiol surrogates for thioether synthesis. This review highlights recent advancements deoxygenative synthesis, categorizing them by reaction types, including cross-coupling reactions, C–H functionalization, hydro/halo/oxy-thiolation unsaturated hydrocarbons. We also discuss representative mechanisms to provide comprehensive understanding these innovative approaches. 1 Introduction 2 Cross-Coupling Reactions 3 Functionalization 4 Hydro/Halo/Oxy-thiolation Unsaturated Hydrocarbons 5 Conclusion

Language: Английский

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Electrochemical N–H Methylsulfoxidation of Sulfoximines with DMSO

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Comprehensive Summary The N–H methylsulfoxidation of sulfoximines using DMSO as a methylsulfinyl source, induced by electrochemistry, has been developed. This method is the first example an electrochemical reaction in which serves source. Unlike previous reactions involving substrate, exclusively proceed via radical mechanisms, this follows S‐cation pathway. A wide range N ‐methylsulfinyl were successfully obtained.

Language: Английский

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Electrochemical regioselective methylthiolation of imidazo[2,1- b ]thiazoles with DMSO

Synthetic Communications, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 21, 2025

Language: Английский

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C3-Alkylation of Imidazo[1,2-a]pyridines via Three-Component Aza-Friedel–Crafts Reaction Catalyzed by Y(OTf)3

Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3463 - 3463

Published: July 24, 2024

As an important class of nitrogen-containing fused heterocyclic compounds, imidazo[1,2-a]pyridines often exhibit significant biological activities, such as analgesic, anticancer, antiosteoporosis, anxiolytic, etc. Using Y(OTf)

Language: Английский

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Bunte Salts for Electrochemical Deuteroalkylthiolation of Heteroarenes

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(19), P. 4084 - 4088

Published: July 23, 2024

Abstract This study presents a strategy for the electrochemical deuteroalkylthiolation of heteroarenes, using Bunte salt as deuterium‐alkylthio source. reaction occurs in an undivided cell without need catalysts, oxidants, or electrolytes, yielding variety deuteroalkylthiolated heteroarenes.

Language: Английский

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Recent Advances on the Construction of Functionalized Indolizine and Imidazo[1,2‐a]pyridine Derivatives

The Chemical Record, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Indolizines and imidazo[1,2‐ a ]pyridines are commonly found in natural products, synthetic drugs, bioactive molecules. These two types of derivatives possess good antibacterial, antiparasitic, anticancer activities, so on. The functionalization indolizines has always been hot topic organic chemistry research made significant progress. In recent years, our group dedicated to developing diverse methods for the preparation such important compounds. 1) We have developed C−H reactions efficient modification parent ]pyridines. 2) A variety cycloaddition were established construction indolizine ]pyridine from simple raw materials. 3) intriguing deconstruction‐functionalization indolizines, enabling reorganization heterocyclic frameworks. This paper outlines group's latest advancements constructing structurally derivatives. hope that this work will offer valuable insights inspiration ongoing field N‐heterocyclic

Language: Английский

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Recent Advances in the Electrochemical Functionalization of Imidazoheterocycles

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

Abstract Imidazoheterocycles have extensive applications in the pharmaceutical industry and agrochemicals. A comprehensive overview has been provided on current advancements electrochemical functionalization of imidazo‐fused heterocycles, which classified into ten different types reactions. Electrochemical synthesis emerged as a highly effective method for producing organic molecules, especially context sustainable development. Employing electrons traceless oxidant, several C−H reactions heterocycles achieved at either C3 or C5 positions. Electrons may serve reducing agent to synthesize pyridine rings that are partially fully saturated imidazo[1,2‐ ]pyridines. The purpose review is attract interest scientific community promote additional research imidazoheterocycles using methods.

Language: Английский

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Transition-metal-free synthesis of triarylmethanes via Friedel-Crafts reactions of imidazo[1,2-a]pyridines with chlorohydrocarbon derivatives

Journal of Saudi Chemical Society, Journal Year: 2024, Volume and Issue: 28(4), P. 101883 - 101883

Published: May 29, 2024

A facile, transition-metal-free, HFIP-promoted method for the synthesis of triarylmethanes through direct Friedel-Crafts reactions imidazo[1,2-a]pyridines with chlorohydrocarbon derivatives has been described, which allows efficient containing in good to satisfactory yields at room temperature. This transformation features simple operation, excellent functional group tolerance, and a broad substrate scope.

Language: Английский

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