Micelle-enabled Bromination of α-Oxo Ketene Dithioacetals: Mild and Scalable Approach via Enzymatic Catalysis DOI
Thao Nguyen Thanh Huynh, Khuyen Thu Nguyen,

Chisanu Krongyut

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

The bromination of α-oxo ketene dithioacetals using KBr/H2O2, catalyzed by Curvularia inaequalis vanadium chloroperoxidase (CiVCPO), has been successfully demonstrated. A comparative study enzymatic processes "on water" versus "in water", 2 wt% the surfactant TPGS-750-M revealed that in-water protocol not only provides higher yields but also accommodates a broader substrate scope. This method in an aqueous micellar medium enabled preparation brominated fair to excellent (23 examples). In system, concentration was increased up 50 mM, and amounts brominating agents KBr H2O2 were reduced approximately 2.0 equivalents without compromising efficiency. Notably, this process allows for gram-scale high yields. Key advantages include its benign eco-friendly nature, use water as green solvent, potential large-scale production dithioacetals.

Language: Английский

Finding suitable biobased solvents for extractions from water DOI Creative Commons
Gerhard König, Pascal Hauk, Fabrice Gallou

et al.

RSC Sustainability, Journal Year: 2025, Volume and Issue: 3(3), P. 1539 - 1549

Published: Jan. 1, 2025

Solvent usage is one of the most critical factors for carbon footprint chemical and pharmaceutical industries, with profound consequences an undesirable or sub-optimal selection.

Language: Английский

Citations

1
Discovery, engineering, and applications of the ketoreductases from Metabacillus lacus in the synthesis of chiral (Hetero)aryl alcohols DOI
Shuling Zhang, Yuqing Zhang, Weixi Kong

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 511, P. 161964 - 161964

Published: March 28, 2025

Language: Английский

Citations

1
Probing the surfactant-constructed microenvironment of PtCu bimetallic nanoalloys to improve catalytic selectivity in aqueous micelles DOI
Yiru Chen, Xi He, Linxi Hou

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156934 - 156934

Published: Oct. 1, 2024

Language: Английский

Citations

1
Micelle-enabled Bromination of α-Oxo Ketene Dithioacetals: Mild and Scalable Approach via Enzymatic Catalysis DOI
Thao Nguyen Thanh Huynh, Khuyen Thu Nguyen,

Chisanu Krongyut

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

The bromination of α-oxo ketene dithioacetals using KBr/H2O2, catalyzed by Curvularia inaequalis vanadium chloroperoxidase (CiVCPO), has been successfully demonstrated. A comparative study enzymatic processes "on water" versus "in water", 2 wt% the surfactant TPGS-750-M revealed that in-water protocol not only provides higher yields but also accommodates a broader substrate scope. This method in an aqueous micellar medium enabled preparation brominated fair to excellent (23 examples). In system, concentration was increased up 50 mM, and amounts brominating agents KBr H2O2 were reduced approximately 2.0 equivalents without compromising efficiency. Notably, this process allows for gram-scale high yields. Key advantages include its benign eco-friendly nature, use water as green solvent, potential large-scale production dithioacetals.

Language: Английский

Citations

0