N,N-Dimethylformamide’s Participation in Domino Reactions for the Synthesis of Se-Phenyl Dimethylcarbamoselenoate Derivatives

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 747 - 747

Published: Feb. 6, 2025

N,N-dimethylformamide’s (DMF) participation in domino reactions has been developed. Starting from substituted halogenobenzenes and selenium powder, versatile biologically active Se-phenyl dimethylcarbamoselenoate derivatives were efficiently synthesized under mild reaction conditions. The mechanism was studied using control experiments. These protocols involve a wider substrate scope provide an economical approach toward C–selenium bond formation.

Language: Английский

Heteroarylation of Organophosphonium Salts with Indoles in Water: Synthesis of Symmetrical and Unsymmetrical 3,3'‐Bisindolylmethane Derivatives

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract A method for the synthesis of symmetrical and unsymmetrical 3,3′‐bis(indolyl)methanes (3,3′‐BIMs) has been developed through direct heteroarylation indolyl‐containing di(hetero)aryl phosphonium salts with indole derivatives in aqueous media. This metal‐free reaction proceeds smoothly under mild conditions, eliminating need hazardous solvents expensive additives/catalysts typically used conventional routes, thereby highlighting synthetic practicality efficiency process. The success this approach is largely attributed to role water as a promoter, facilitating C−P bond functionalization salts. Furthermore, demonstrates broad substrate scope, good functional group tolerance, excellent scalability. Moreover, protocol can also be extended triindolylmethane compound diarylmethylated indole.

Language: Английский