Synthesis of 2-Organoselenyl Quinolines via Electro-Oxidative Selenocyclization of Isocyanides
Peng‐Fei Huang,
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Jia-Le Fu,
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Zhi-Gang Quan
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et al.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
Organoselenium
compounds
and
quinolines
are
widely
used
in
drugs
materials.
Herein,
we
report
an
electro-oxidative
cyclization
between
isocyanides
diselenides
to
effectively
synthesize
2-organoselenyl
a
simple
undivided
cell
without
transition-metal
catalysts
or
toxic
oxidants.
Gram-scale
synthesis
postsynthetic
modifications
highlighted
the
practicality
of
this
electrochemical
strategy.
A
series
produced
with
up
82%
yield,
good
functional
group
tolerance
high
atom
efficiency
under
room
temperature.
Language: Английский
Electrochemical Synthesis of 4‐Selenylated Oxazolones via Oxyselenylation of Ynamides
Jinhui Cai,
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Kaili Cen,
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Weishuang Li
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et al.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 19, 2024
Abstract
Electrosynthesis
of
selenylated‐oxazolone
derivatives
via
cascade
selenylation/cyclization
ynamides
was
disclosed.
A
series
diaryl
diselenides,
dialkyl
and
heteroaryl‐substituted
tolerated
in
this
protocol
delivered
4‐selenyloxazolones
28–83%
yields.
The
scale‐up
reaction
the
oxidation
performed
to
showcase
practicability
method.
Furthermore,
mechanistic
experiments
indicated
that
a
cationic
pathway
instead
radical
probably
involved.
Language: Английский