Advancements in nanotechnology-driven photodynamic and photothermal therapies: mechanistic insights and synergistic approaches for cancer treatment DOI Creative Commons

S. Sameera Shabnum,

Siranjeevi Ravichandran,

C. Krishna Raj

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(52), P. 38952 - 38995

Published: Jan. 1, 2024

Cancer is a disease that involves uncontrolled cell division triggered by genetic damage to the genes control growth and division. starts as localized illness, but subsequently spreads other areas in human body (metastasis), making it incurable. second most prevalent cause of mortality worldwide. Every year, almost ten million individuals get diagnosed with cancer. Although different cancer treatment options exist, such chemotherapy, radiation, surgery immunotherapy, their clinical efficacy limited due significant side effects. New options, phototherapy, which employs light for cancer, have sparked growing fascination research community. Phototherapies are classified into two types: photodynamic (PDT) photothermal therapy (PTT). PDT necessitates use photosensitizing chemical exposure at certain wavelength. Photodynamic primarily based on creation singlet oxygen stimulation photosensitizer, then used kill tumor cells. can be treat variety malignancies. On hand, PTT molecule activates destroys cells longer wavelengths light, less energetic hence hazardous tissues. While better alternative standard therapy, some irradiation circumstances, cellular necrosis, results pro-inflammatory reactions harmful therapeutic effectiveness. Latest has revealed may adjusted produce apoptosis instead attractive since reduces inflammatory response.

Language: Английский

Porphyrin-based electrospun nanomaterials for life science applications DOI Creative Commons
Ana C. Mendes, Nuno M. M. Moura, M. Amparo F. Faustino

et al.

BBA Advances, Journal Year: 2025, Volume and Issue: 7, P. 100160 - 100160

Published: Jan. 1, 2025

Porphyrins are renowned for their utility in photocatalysis, electronics, sensors, solar cell dyes, and environmental remediation. However, potential life sciences applications remains underexplored, particularly the context of encapsulation via electrospinning. This review examines recent advancements (2000-2025) electrospinning techniques encapsulating porphyrins, highlighting unique properties, bioactivities, versatile sciences. By combining strengths porphyrins technology, researchers can unlock transformative solutions various life-science challenges, which include photodynamic therapy (PDT), composite materials anti-microbial applications, drug delivery. These efforts could push porphyrin-encapsulated from research concepts to applied societal solutions, addressing critical needs healthcare beyond other fields.

Language: Английский

Citations

0
Advancements in nanotechnology-driven photodynamic and photothermal therapies: mechanistic insights and synergistic approaches for cancer treatment DOI Creative Commons

S. Sameera Shabnum,

Siranjeevi Ravichandran,

C. Krishna Raj

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(52), P. 38952 - 38995

Published: Jan. 1, 2024

Cancer is a disease that involves uncontrolled cell division triggered by genetic damage to the genes control growth and division. starts as localized illness, but subsequently spreads other areas in human body (metastasis), making it incurable. second most prevalent cause of mortality worldwide. Every year, almost ten million individuals get diagnosed with cancer. Although different cancer treatment options exist, such chemotherapy, radiation, surgery immunotherapy, their clinical efficacy limited due significant side effects. New options, phototherapy, which employs light for cancer, have sparked growing fascination research community. Phototherapies are classified into two types: photodynamic (PDT) photothermal therapy (PTT). PDT necessitates use photosensitizing chemical exposure at certain wavelength. Photodynamic primarily based on creation singlet oxygen stimulation photosensitizer, then used kill tumor cells. can be treat variety malignancies. On hand, PTT molecule activates destroys cells longer wavelengths light, less energetic hence hazardous tissues. While better alternative standard therapy, some irradiation circumstances, cellular necrosis, results pro-inflammatory reactions harmful therapeutic effectiveness. Latest has revealed may adjusted produce apoptosis instead attractive since reduces inflammatory response.

Language: Английский

Citations

1