Synthesis of New Azoles For the Treatment of Resistant Infections Caused By Who Critical Priority Fungi: Therapeutic Challenges and Innovations in The Fight Against Them
Revista de Gestão Social e Ambiental,
Journal Year:
2025,
Volume and Issue:
19(3), P. e011670 - e011670
Published: March 20, 2025
Objective:
The
study
aimed
to
conduct
a
review
of
new
azoles
derivatives
tackle
the
critical
priority
pathogens
World
Health
Organization
(WHO).
Theoretical
background:
Azoles
are
main
class
antifungal
drugs,
and
creation
drugs
based
on
their
fundamental
structure
could
be
viable
alternative
for
combating
listed
by
WHO
as
due
high
mortality
resistance.
Method:
used
databases
such
PubMed,
Scopus
Science
Direct,
with
articles
published
between
2019
2024.
Papers
addressing
infections
caused
these
fungi
azole
an
against
were
included,
20
selected.
Results
discussion:
list
highlights
Candida
albicans,
Cryptococcus
neoformans,
Aspergillus
fumigatus
auris,
which
in
urgent
need
therapeutic
alternatives.
Experimental
studies
have
revealed
significant
advances
structural
modification
azoles,
especially
relation
hybrid
compounds
combining
triazole
oxadiazole
nuclei
containing
hydrophobic
substituents,
broad
spectrum
mechanisms
action.
Research
implications:
Resistance
has
increased
globally
threatens
effectiveness
available
treatments.
synthesis
can
help
fill
gaps,
modifications
serve
basis
development
improved
Originality
value:
Novel
molecules,
combination
cores,
introduction
groups,
not
only
increase
efficacy,
but
also
improve
penetration
into
biofilms
thermal
stability.
These
innovations
represent
advance
treatment
fungal
therapies.
Language: Английский
Hybrid Bis-(Imidazole/Benzimidazole)-Pyridine Derivatives with Antifungal Activity of Potential Interest in Medicine and Agriculture via Improved Efficiency Methods
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(4), P. 495 - 495
Published: March 28, 2025
Background/Objectives:
Nowadays
fungal
infections
are
rising
serious
threats
for
the
human
health
system
and
agriculture,
mostly
because
of
antifungal
resistance,
emergence
new
pathogens
adverse
effects,
pressing
scientific
world
exploration
compounds.
Therefore,
aim
this
work
was
to
synthesize
study
activity
against
plant
fungi
a
class
hybrid
bis-(imidazole/benzimidazole)-pyridine
salt
derivatives.
Methods:
The
synthesis
derivatives
performed
using
both
conventional
thermal
heating
ultrasound
irradiation
methods.
Results:
use
has
advantages
dramatic
decrease
in
reaction
time
and,
consequently,
notable
acceleration
rate,
remarkable
consumed
energy
higher
yields.
five
strains
determined
by
disk
diffusion
method
minimum
inhibitory
concentration.
Conclusions:
tested
manifest
good
strains.
Some
compounds
have
very
quasi-nonselective
pathogenic
fungi,
some
cases
close
control
drug
fluconazole,
respectively,
many
agents
commercially
used
protection.
Language: Английский