Self‐Assembled Short Peptide Amphiphile‐Gold Nanostructures: A Novel Approach for Bacterial Infection Treatment DOI

N. Swain,

Ramesh Singh, Aanand Kautu

et al.

Chemistry - An Asian Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

This study presents a simple and effective strategy for synthesizing biocompatible hybrid nanostructures composed of short peptide amphiphiles (sPA) gold nanoparticles (AuNPs) bacterial infection control. The self-assembling sPA molecules form stable β-sheet structures, which are further enhanced upon the addition ions (Au(III)) brief sunlight exposure, leading to formation functional AuNP-sPA nanostructures. Comprehensive spectroscopic microscopic characterization confirms successful integration AuNPs with sPA, resulting in nanomaterials potent antibacterial properties. conjugates exhibit superior activity against Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa high selectivity biocompatibility minimal cytotoxicity, reinforcing their therapeutic potential. These findings highlight as promising alternatives conventional antibiotics targeted treatment.

Language: Английский

Self‐Assembled Short Peptide Amphiphile‐Gold Nanostructures: A Novel Approach for Bacterial Infection Treatment DOI

N. Swain,

Ramesh Singh, Aanand Kautu

et al.

Chemistry - An Asian Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

This study presents a simple and effective strategy for synthesizing biocompatible hybrid nanostructures composed of short peptide amphiphiles (sPA) gold nanoparticles (AuNPs) bacterial infection control. The self-assembling sPA molecules form stable β-sheet structures, which are further enhanced upon the addition ions (Au(III)) brief sunlight exposure, leading to formation functional AuNP-sPA nanostructures. Comprehensive spectroscopic microscopic characterization confirms successful integration AuNPs with sPA, resulting in nanomaterials potent antibacterial properties. conjugates exhibit superior activity against Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa high selectivity biocompatibility minimal cytotoxicity, reinforcing their therapeutic potential. These findings highlight as promising alternatives conventional antibiotics targeted treatment.

Language: Английский

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