European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 987, P. 177075 - 177075
Published: Nov. 8, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Oct. 14, 2024
Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against
Language: Английский
Citations
50
Schizophrenia, Journal Year: 2025, Volume and Issue: 11(1)
Published: Jan. 11, 2025
Oxidative stress (OS) is crucial in schizophrenia (SCZ) pathology. Ferroptosis, a recently discovered cell death pathway linked to OS, might contribute the development of SCZ. This study investigated association between ferroptosis markers and cognitive impairments chronic SCZ patients. A retrospective analysis was conducted on 204 patients with deficits 216 healthy controls (HC) matched for relevant characteristics. Plasma levels OS markers, including iron, ferritin (FE), transferrin (TF), glutathione peroxidase 4 (GPX4), long-chain acyl-CoA synthetase (ACSL4), (GSH), sirtuin 1 (SIRT1), nuclear factor erythroid 2-related 2 (Nrf2), malondialdehyde (MDA), superoxide dismutase (SOD) were measured. Standardized assessments like positive negative syndrome scale (PANSS), Montreal Cognitive Assessment (MoCA) used evaluate psychiatric symptoms, function. showed significant differences compared HC group (P < 0.01). Multiple linear regression revealed that decreased GSH iron levels, along elevated SOD significantly associated overall severity symptoms. Additionally, reduced GPX4 increased ACSL4 FE symptoms impairments. Notably, emerged as key predictor function abstraction language domains. Our alterations altered plasma GPX4, GSH, ACSL4, FE, patients, which indicate close biomarkers observed these individuals.
Language: Английский
Citations
0
Planta Medica, Journal Year: 2025, Volume and Issue: unknown
Published: March 14, 2025
Abstract Alzheimerʼs disease is a progressive neurodegenerative disorder characterized by tau protein hyperphosphorylation and neurofibrillary tangle formation, which are central to its pathogenesis. This review focuses on the therapeutic potential of natural products in targeting phosphorylation, key factor progression. It comprehensively summarizes current research various compounds, including flavonoids, alkaloids, saponins, polysaccharides, phenols, phenylpropanoids, terpenoids, highlighting their multitarget mechanisms, such as modulating kinases phosphatases. The ability these compounds mitigate oxidative stress, inflammation, pathology while enhancing cognitive function underscores value anti-Alzheimerʼs therapeutics. By integrating recent advances extraction methods, pharmacological studies, artificial intelligence-driven screening technologies, this provides valuable reference for future development product-based interventions disease.
Language: Английский
Citations
0
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 22, 2025
Alzheimer's disease (AD) is a chronic neurodegenerative of the central nervous system caused by loss neuronal or myelin function, accompanied ferroptosis. Astragalus membranaceus (Fisch.) Bge. (A. membranaceus) one China's homologous lists medicines and food, its active component saponins have neuroprotective effects. This study examines mechanism from A. (AS) in treating AD. UPLC-Q-TOF-MS analyzed composition AS. Ferroptosis models were established to evaluate anti-AD efficacy. As result, AS treatment inhibited ferroptosis SAMP8 mice restoring iron homeostasis lipid peroxidation (LPO) balance brain, thereby improving cognitive impairment pathological damage. Mechanistically, reduced Fe2+, MDA, ROS levels enhanced protein SLC7A11, GPX4, FTH1, FPN1. NADPH oxidase 4 (NOX4) overexpression revealed that NOX4, reducing NOX4 stability regulating NOX4/Nrf2 pathway erastin-injured HT22 cells significantly alleviating Therefore, improved AD rebuilding LPO brain. has potential be promising candidate medicine for
Language: Английский
Citations
0
European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177605 - 177605
Published: April 1, 2025
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133578 - 133578
Published: July 1, 2024
Language: Английский
Citations
2
Neuropharmacology, Journal Year: 2024, Volume and Issue: 259, P. 110083 - 110083
Published: July 21, 2024
Language: Английский
Citations
1
Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107404 - 107404
Published: Sept. 19, 2024
Language: Английский
Citations
1
European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 987, P. 177075 - 177075
Published: Nov. 8, 2024
Language: Английский
Citations
1