Emerging Applications of Nanoparticles in the Diagnosis and Treatment of Breast Cancer

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(7), P. 723 - 723

Published: July 4, 2024

Breast cancer remains the most prevalent among women worldwide, driving urgent need for innovative approaches to diagnosis and treatment. This review highlights pivotal role of nanoparticles in revolutionizing breast management through advancements interconnected including targeted therapy, imaging, personalized medicine. Nanoparticles, with their unique physicochemical properties, have shown significant promise addressing current treatment limitations such as drug resistance nonspecific systemic distribution. Applications range from enhancing delivery systems sustained release developing diagnostic tools early precise detection metastases. Moreover, integration into photothermal therapy synergistic use existing treatments, immunotherapy, illustrate transformative potential care. However, journey towards clinical adoption is fraught challenges, chemical feasibility, biodistribution, efficacy, safety concerns, scalability, regulatory hurdles. delves state nanoparticle research, applications diagnosis, obstacles that must be overcome integration.

Language: Английский

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Next-Generation Immunotherapy: Advancing Clinical Applications in Cancer Treatment

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(21), P. 6537 - 6537

Published: Oct. 30, 2024

Next-generation immunotherapies have revolutionized cancer treatment, offering hope for patients with hard-to-treat tumors. This review focuses on the clinical applications and advancements of key immune-based therapies, including immune checkpoint inhibitors, CAR-T cell therapy, new vaccines designed to harness system combat malignancies. A prime example is success pembrolizumab in treatment advanced melanoma, underscoring transformative impact these therapies. Combination treatments, integrating immunotherapy chemotherapy, radiation, targeted are demonstrating synergistic benefits improving patient outcomes. also explores evolving role personalized immunotherapy, guided by biomarkers, genomic data, tumor environment, better target individual Although significant progress has been made, challenges such as resistance, side effects, high costs persist. Technological innovations, nanotechnology artificial intelligence, explored future enablers The evaluates trials, breakthroughs, emerging immune-modulating agents delivery systems that hold great promise enhancing efficacy, reducing toxicity, expanding access immunotherapy. In conclusion, this highlights ongoing reshaping care, strategies poised overcome current further extend therapeutic reach.

Language: Английский

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Development of pyrazolo[1,5-a]pyrimidine-grafted coumarins as selective carbonic anhydrase inhibitors and tubulin polymerization inhibitors with potent anticancer activity

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140462 - 140462

Published: Jan. 1, 2025

Language: Английский

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Pectin from fruit peel: A comprehensive review on various extraction approaches and their potential applications in pharmaceutical and food industries

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100708 - 100708

Published: Feb. 1, 2025

Language: Английский

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From Pioneering Discoveries to Innovative Therapies: A Journey Through the History and Advancements of Nanoparticles in Breast Cancer Treatment

Breast Cancer Targets and Therapy, Journal Year: 2025, Volume and Issue: Volume 17, P. 27 - 51

Published: Jan. 1, 2025

Nanoparticle technology has revolutionized breast cancer treatment by offering innovative solutions addressing the gaps in traditional methods. This paper aimed to comprehensively explore historical journey and advancements of nanoparticles treatment, highlighting their transformative impact on modern medicine. The discussion traces evolution nanoparticle-based therapies from early conceptualization current applications future potential. We initially explored context limitations conventional therapies, such as surgery, radiation, chemotherapy. advent nanotechnology introduced a new era characterized development various nanoparticles, including liposomes, dendrimers, gold designed target cells with remarkable precision. further described mechanisms action for passive active targeting, reviewed significant breakthroughs clinical trials that have validated efficacy. Current been examined, showcasing clinically approved comparing effectiveness article also discusses latest nanoparticle research, drug delivery systems combination therapy innovations, while technical, biological, regulatory challenges. technical challenges include efficient targeted tumor sites without affecting healthy tissue; potential toxicity, immune system activation, or resistance mechanisms; economic, involving high production scaling costs; regulatory, requiring rigorous testing safety, efficacy, long-term effects meet stringent approval standards. Finally, we emerging trends, personalized medicine, ethical social implications this technology. In conclusion, through comprehensive analysis case studies, underscores profound

Language: Английский

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Enhancing breast cancer treatment: Evaluating the efficacy of hyaluronic acid-coated tamoxifen-loaded solid lipid nanoparticles on MCF7 cells

Human & Experimental Toxicology, Journal Year: 2025, Volume and Issue: 44

Published: Feb. 20, 2025

Introduction Tamoxifen (TMX) shows promise in treating breast cancer, but it faces challenges such as poor solubility, instability, and incomplete release when targeting tumors. Additionally, TMX therapy’s toxicity is a critical issue cancer treatment. This study aimed to assess the impact of hyaluronic acid (HA)-coated TMX-loaded solid lipid nanoparticles (HA-TMX-SLNs) on MCF7 cells. Methods Solid (SLNs) were prepared using hot homogenization. The HA-TMX-SLNs TMX-SLNs characterized evaluated through transmission electron microscopy (TEM). Cytotoxicity was assessed MTT assay, Western blot analysis utilized identify key factors cell cycle apoptosis. Results demonstrated approximately 55% loading efficiency after 100 h. exhibited lower cytotoxicity cells compared other treatments. Significant decreases expression levels cyclin-dependent kinase (CDK) 4, Cyclin D1, CDK2, Bcl2 observed treatment with HA-TMX-SLNs, along an increase cleaved/procaspase-7. Discussion vitro showed that HA-coated SLNs consistently released drug into media under controlled conditions. Furthermore, cytotoxic effects, increasing apoptosis inhibiting proliferation. These findings suggest effectively deliver

Language: Английский

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αvβ3 integrin aptamer functionalized pH-responsive lipid polymer hybrid nanoparticles for targeted co-delivery of paclitaxel and tamoxifen

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141754 - 141754

Published: March 4, 2025

Language: Английский

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New developments in the nanocarrier-based drug delivery system for the treatment of breast cancer

Asia-Pacific Journal of Pharmacotherapy & Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 33 - 43

Published: March 24, 2025

Worldwide, breast cancer remains the leading cause of disease and mortality for women. Because its aggressive nature resistance to conventional medicines, triple negative (TNBC) is very challenging treat. Through focused tactics, recent advancements in nanocarrier technology have demonstrated promise improving medication delivery, optimizing bioavailability, raising drug concentrations at tumor locations. Nanoparticles become a useful tool studying imaging, diagnosis, targeting cancer. Their advanced physicochemical properties contribute prolonged circulation bloodstream, as well more efficient cells. The accuracy with which nanoparticles can target tumors improved by both passive takes advantage characteristics like leaky vasculature, microenvironment, or direct application active makes use receptor-specific antibodies. By enhancing their ability cells, provide an over formulations that they lessen cytotoxic effects anticancer drugs. Numerous based on exist different phases preclinical clinical development; most extensively investigated include polymeric micelles, liposomes, dendrimers, carbon nanotubes, nanorods. Polymeric liposomes been popular delivery vehicles therapy during last ten years. Ongoing studies have, however, shown number these carriers' drawbacks. Consequently, there has interest hybrid nanoparticles, combine advantages nanoparticles. An overview developments field using given this study. It also stresses need early identification patient outcomes potential nanocarriers transform BC treatment.

Language: Английский

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Eco-Friendly Nanotherapeutics: Metallic Nanoparticles for Targeting Breast Cancer

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177603 - 177603

Published: April 1, 2025

Language: Английский

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Nanostructured materials for breast cancer therapeutics enhancing drug delivery through nanofibers, nano-mesh, and nanoflowers

Next Nanotechnology, Journal Year: 2025, Volume and Issue: 8, P. 100159 - 100159

Published: Jan. 1, 2025

Language: Английский

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