Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155785 - 155785
Published: Dec. 19, 2024
Language: Английский
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114675 - 114675
Published: April 1, 2025
Language: Английский
Citations
0
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189315 - 189315
Published: April 1, 2025
Language: Английский
Citations
0
Results in Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 100529 - 100529
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Rare Earths, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
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0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 24, 2025
The effective treatment of Alzheimer's disease (AD) is challenging because its complex and controversial pathological mechanisms. Moreover, multiple barriers, such as the blood-brain barrier (BBB), reduce drug delivery efficiency. Microglia-related neuroinflammation has recently attracted increasing attention a possible cause AD become novel therapeutic target. Therefore, overcoming BBB targeted anti-inflammatory agents to microglia seem be practical strategies for treating AD. A large proportion natural active extracts possess exceptional immunomodulating capabilities. In this study, cooperative berberine (Ber) palmatine (Pal) by transferrin-decorated extracellular vesicles (Tf-hEVs-Ber/Pal), which can cross precisely target microglia, was performed. This nanosystem effectively cleared amyloid β-protein (Aβ) aggregates, significantly regulated neuroinflammatory environment both in vitro vivo markedly altered behavior improved cognitive learning abilities model mice. efficacy microglia-targeting combined approach demonstrated, broadens potential application Chinese herbal ingredients.
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 28, 2025
The human oral cavity harbors a diverse microbiota, including Streptococcus species. Oral mucosal wounds heal rapidly, although the exact cause remains unclear. This study investigates impact of mutans-derived extracellular vesicles (Sm EVs) on wound healing in both organoids and mouse skin. To explore whether microbial EV RNA cargo influences healing, sequences from Sm EVs were identified, most abundant synthesized into oligomers encapsulated E. coli (Ec for further vivo testing. We assessed role Toll-like receptor 3 (TLR3) mechanism TLR3 knockout (KO) mice. significantly enhanced cell proliferation migration mucosa, with focal adhesion complex formation. improved dorsal skin compared to PBS controls. sequencing revealed that bacterial tRNAs, particularly tRNA-Met variant (Oligo 1), RNAs EVs. Ec carrying Oligo 1 produced similar effects However, mice, did not improve healing. highlights EVs, their tRNA variants, promoting through TLR3-dependent mechanism. These findings suggest commensal bacteria may offer therapeutic potential chronic, non-healing wounds.
Language: Английский
Citations
0
Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(9)
Published: April 29, 2025
Cancer is an escalating global health issue, with rising incidence rates annually. Chemotherapy, a primary cancer treatment, often exhibits low tumor-targeting efficiency and severe side effects, limiting its effectiveness. Recent research indicates that exosomes, due to their immunogenicity molecular delivery capabilities, hold significant potential as drug carriers for tumor treatment. This review summarizes the current status, powerful therapeutic potential, challenges of using exosomes treatment tumors. Exosomes are crucial in diagnosis, onset, progression. To improve efficacy exosome-based treatments, researchers exploring various biological, physical, chemical approaches engineer new nanomedicine translational therapy platform broad alterable capabilities. Numerous clinical trials currently underway investigating safety tolerability carrying drugs specific sites can be engineered deliver molecules cells tissues, offering novel approach disease
Language: Английский
Citations
0
Molecular Immunology, Journal Year: 2025, Volume and Issue: 183, P. 18 - 32
Published: May 2, 2025
Language: Английский
Citations
0
International Journal of Applied Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 80 - 92
Published: May 7, 2025
Parkinson’s Disease (PD), a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, is closely associated with neuroinflammation mediated exosomes. This review discusses role exosomes in modulation neuroinflammatory processes PD. Small Extracellular Vesicles (EVs) are that communicate between cells transporting proteins, lipids, and RNAs affect neuronal health. We investigated how propagate misfolded α-synuclein proinflammatory mediators, leading to microglial activation neurodegeneration. The key questions addressed include following: (1) How do promote spread pathology? (2) What molecular pathways drive exosome-mediated PD? (3) Can serve as diagnostic biomarkers or therapeutic vehicles? By analyzing these mechanisms, this underscores dual exacerbating disease progression their potential for innovative treatments. finding highlights challenges current methodologies future prospects exosome-targeted therapy
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 107033 - 107033
Published: May 1, 2025
Language: Английский
Citations
0