An insight into Cell-Penetrating Peptides: Perspectives on Design, Optimization, and Targeting in Drug Delivery Systems

Pharmaceutical Development and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 34

Published: May 13, 2025

The authors carried out a comprehensive review of the application peptides known as cell-penetrating (CPPs) in various drug delivery systems (DDS), with prospect achieving novel solutions and ideas to overcome challenges DDS, by making them more able penetrate cells biological membranes. A conceptual search was conducted relevant literature databases (Scopus, PubMed, Web Science, Google Scholar) up 1 April 2025 using keywords such systems, peptides, CPPs, complexes, conjugates, nanoparticles, dendrimers, exosomes, liquid crystalline, liposomes, micelles, nanospheres lipid nanoparticles. studies demonstrate that antimicrobial effect drugs, including curcumin, gentamicin, antifungal drugs like imidazoacridinone derivatives, can be enhanced when they are conjugated or complexed CPPs. CPPs possess positive charges, which make suitable for gene therapy applications facilitating plasmids siRNAs negative charges modern systems. Medicinal formulations containing combination crystals nanostructured carriers (NLCs) increase penetration skin. Additionally, several investigations showed could have impact on pharmacokinetic pharmacodynamic chemotherapy agents, reducing their side effects. significant potential enhancing penetration, bioavailability, targeting, optimization DDS. By computer modeling designing desirable features conducting clinical studies, new methods treating diseases better achieved.

Language: Английский

Exosomes: A potential therapeutic strategy to fight cancer as drug carriers or immune system regulators

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 189238 - 189238

Published: Dec. 1, 2024

Language: Английский

Exosome-Mediated Delivery of CRISPR-Cas9: A Revolutionary Approach to Cancer Gene Editing

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155785 - 155785

Published: Dec. 19, 2024

Language: Английский