The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: May 16, 2025
In this study, we reported the utilization of vinylsulfonium salt as a highly efficient dipolarophile, leveraging facile leaving ability its sulfide moiety, to engage in [3 + 2] cycloaddition with N-amino(iso)quinolinium salts. This approach facilitates construction various C1/C2-unsubstituted pyrazolo(iso)quinoline skeletons. The transformation is conducted under catalyst- and external oxidant-free conditions. Furthermore, extended gram-scale reaction demonstrates practical applicability developed protocol.
Language: Английский