Precision Metal Nanoclusters Meet Proteins: Crafting Next-Gen Hybrid Materials

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Metal nanoclusters (NCs), owing to their atomic precision and unique molecule-like properties, have gained widespread attention for applications ranging from catalysis bioimaging. In recent years, proteins, with hierarchical structures diverse functionalities, emerged as good candidates functionalizing metal NCs, rendering NC–protein conjugates combined even synergistically enhanced properties featured by both components. this Perspective, we explore key questions regarding why proteins serve complementary partners the methodologies available conjugating characterization techniques necessary elucidate interactions within emerging bionano system. We also highlight of in biomedicine, catalysis, biosensing which hybrid demonstrate remarkable performance. Furthermore, challenges hampering further development conjugates, include understanding binding mechanisms, expanding diversity used conjugation, exploiting individual roles NCs systems, are discussed. This Perspective aims systemize current synthetic design principles adding acceptance nanotechnology.

Language: Английский

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Novel NIR-Ⅱ-Activated titanate-supported iridium nanoplatform delivers multimodal antitumor therapy synergistic with PD-1 inhibition in TNBC

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160659 - 160659

Published: Feb. 1, 2025

Language: Английский

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Halide‐Directed Ligand Engineering Enables Expedient, Controlled and Divergent Syntheses of Diphosphine‐Protected Au Nanoclusters

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Despite substantial progress in ligand engineering, the efforts field of Au nanoclusters have been concentrated almost exclusively on organic ligands. Halides, most typical auxiliary inorganic ligands widely present clusters, remain virtually unexplored, particularly regarding their effects cluster construction. Herein, diphosphine Ph2P(CH2)nPPh2 (Ln, n = 1-6) is chosen as co-protecting and a comparative analysis influential roles halide ions (Cl-, Br-, I-) guiding synthesis conducted. A simple yet efficient halide-directed synthetic approach has developed series nanoclusters, including known [Au18(L1)6Br4]2+, [Au13(L2)5Cl2]3+ [Au8(L3)4Cl2]2+ that however crystallized new polymorphic forms, well reduction-active [Au18(L1)6Cl4]2+, luminescence-enhanced [Au14(L3)5Br4]2+ core-isomeric [Au11(Ln)4X2]+ (n 4-6; X Cl, Br, I), are obtained more expedient controllable manner. This work clearly demonstrates non-negligible directing synthesis, provides an easier access to diverse diphosphine-protected nanoclusters. approach, promising gram-scale expected further extend scope holds promise for advancing diversified syntheses broader range ligand-protected metal

Language: Английский

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Glutathione: A Naturally-occurring Tripeptide for Functional Metal Nanomaterials

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Glutathione's role in synthesizing functional metal nanomaterials with unique optical properties and nanobiomedical applications.

Language: Английский

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Assessing the photoluminescence of metal nanoclusters: The Individual versus the collective

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111155 - 111155

Published: March 1, 2025

Language: Английский

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Recent progress in atomically precise metal nanoclusters: From bio-related properties to biological applications

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216633 - 216633

Published: March 30, 2025

Language: Английский

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γ-cyclodextrin metal-organic framework-activated gold nanoclusters with water solubility as multi-enzyme mimics for simultaneous detection of pesticide and cholinesterase activity

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 344093 - 344093

Published: April 1, 2025

Language: Английский

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Investigating the composition of the layer formed on Au NRs by NADH reduction and its application in SERS detection of Cu2+

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126312 - 126312

Published: April 1, 2025

Language: Английский

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Rethinking the stability of metal nanoclusters: the individual versus the collective

Nanoscale, Journal Year: 2024, Volume and Issue: 16(24), P. 11513 - 11517

Published: Jan. 1, 2024

This work demonstrated that the stability of a nanocluster-based crystalline system should be assessed from both cluster individual and collective aspects.

Language: Английский

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Engineering in situ growth of Au nanoclusters on hydrophilic paper fibres for fluorescence calligraphy-based chemical logic gates and information encryption

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 9(11), P. 2007 - 2015

Published: Jan. 1, 2024

Gold nanoclusters (AuNCs) are a type of rising-star fluorescence nanomaterials, but their properties and applications hindered by the multi-step synthesis purification routes, as well lack desired supporting substrates. To enhance optical performance working efficiency, AuNCs suggested to be merged with emerging Herein, glutathione-modified hydrophilic rice papers incubated in chloroauric acid aqueous solutions, oxidation-reduction reaction between glutathione Au ions enables situ formation fluorescent on solid fibres papers. The growth resulted eye-catching tracks, similar traditional Chinese conventional calligraphy; thus, this fluoresence calligraphy is defined work. entire process, including signal responses, extremely simple, rapid, repeatable. Moreover, diversity additive chemical reagents studied responsive calligraphy, as-synthesized AuNC materials exhibited high reliability stability. Significantly, integration synchronous application paper substrates, high-performance logical gates information encryption systems were constructed, remarkably facilitating progress molecular sensing important transmission.

Language: Английский

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