Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
27, P. 101153 - 101153
Published: July 14, 2024
The
advantage
of
low-temperature
forming
through
direct
ink
writing
(DIW)
3D
printing
is
becoming
a
strategy
for
the
construction
innovative
drug
delivery
systems
(DDSs).
Optimization
complex
formulation,
including
factors
such
as
ink,
presence
solvents,
and
potential
low
mechanical
strength,
are
challenges
during
process
development.
This
study
presents
an
application
DIW
to
fabricate
water-soluble,
high-dose,
sustained-release
DDSs.
Utilizing
poorly
compressible
metformin
hydrochloride
model
drug,
core-shell
system
was
developed,
featuring
core
composed
96
%
powder
4
binder,
with
shell
structure
serving
drug-release
barrier.
design
aligns
profile
traditional
processes,
achieving
25.8
reduction
in
volume
enhanced
strength.
facilitates
sustained
release
high-dose
water-soluble
formulations
over
12
h,
potentially
improving
patient
compliance
by
reducing
formulation
size.
Process
optimization
multi-batch
flexibility
were
also
explored
this
study.
Our
findings
provide
valuable
reference
development
DDSs
3D-printed
drugs.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(8), P. 5268 - 5278
Published: Aug. 2, 2024
Currently
the
prevalence
of
diabetic
wounds
brings
a
huge
encumbrance
onto
patients,
causing
high
disability
and
mortality
rates
major
medical
challenge
for
society.
Therefore,
in
this
study,
we
are
targeting
to
fabricate
aloe
vera
extract
infused
biocompatible
nanofibrous
patches
facilitate
process
wound
healing.
Additionally,
clindamycin
has
been
adsorbed
surface
in-house
synthesized
ceria
nanoparticles
again
used
separately
design
web,
as
nanoceria
can
act
good
drug
delivery
vehicle
exhibit
both
antimicrobial
antidiabetic
properties.
Various
physicochemical
characteristics
such
morphology,
porosity,
chemical
composition
produced
webs
were
investigated.
Bacterial
growth
inhibition
antibiofilm
studies
materials
confirm
its
antibacterial
efficacy
against
Gram-positive
Gram-negative
bacteria.
An
vitro
release
study
confirmed
that
mat
show
sustained
pattern
(90%
96
h).
The
web
containing
loaded
not
only
showed
superior
performance
but
also
promoted
greater
contraction
(95
±
2%)
diabetes-induced
mice
just
7
days.
Consequently,
it
efficaciously
lowers
serum
glucose
level,
inflammatory
cytokines,
oxidative
stress,
hepatotoxicity
markers
endorsed
by
various
ex
vivo
tests.
Conclusively,
in-house-fabricated
patch
potential
medicated
suppository
be
treating
proximate
future.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
27, P. 101153 - 101153
Published: July 14, 2024
The
advantage
of
low-temperature
forming
through
direct
ink
writing
(DIW)
3D
printing
is
becoming
a
strategy
for
the
construction
innovative
drug
delivery
systems
(DDSs).
Optimization
complex
formulation,
including
factors
such
as
ink,
presence
solvents,
and
potential
low
mechanical
strength,
are
challenges
during
process
development.
This
study
presents
an
application
DIW
to
fabricate
water-soluble,
high-dose,
sustained-release
DDSs.
Utilizing
poorly
compressible
metformin
hydrochloride
model
drug,
core-shell
system
was
developed,
featuring
core
composed
96
%
powder
4
binder,
with
shell
structure
serving
drug-release
barrier.
design
aligns
profile
traditional
processes,
achieving
25.8
reduction
in
volume
enhanced
strength.
facilitates
sustained
release
high-dose
water-soluble
formulations
over
12
h,
potentially
improving
patient
compliance
by
reducing
formulation
size.
Process
optimization
multi-batch
flexibility
were
also
explored
this
study.
Our
findings
provide
valuable
reference
development
DDSs
3D-printed
drugs.
