Intranasal Administration of Acetaminophen-Loaded Poly(lactic-co-glycolic acid) Nanoparticles Increases Pain Threshold in Mice Rapidly Entering High Altitudes DOI Creative Commons
Qingqing Huang, Xingyue Han, Li Jin

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 341 - 341

Published: March 6, 2025

Background/Objectives: Orally or intravenously administered acetaminophen experiences considerable liver first-pass elimination and may cause liver/kidney damage. This work examined the pharmacological effects of acetaminophen-loaded poly(lactic-co-glycolic acid) nanoparticles (AAP PLGA NPs) intranasally to mice rapidly entering high altitudes. Methods: AAP NPs were prepared using ultrasonication-assisted emulsification solvent evaporation characterized in terms drug encapsulation efficiency loading, vitro vivo release behaviors, toxicity hippocampal neurons. In fluorescence imaging was used monitor concentrations (labeled with indocyanine green) brain blood after intranasal administration. The these on pain threshold altitudes evaluated through hot plate tail flick experiments. Results: found be noncytotoxic, highly biocompatible stable, a loading capacity 42.53% 3.87%, respectively. lasted for up 72 h, rate ~82%. After administration vivo, occurred slowly, mainly concentrated brain. Compared nonencapsulated acetaminophen, resulted higher levels delayed its elimination, thus increasing Conclusions: proposed strategy addresses common problems (low retention time bioavailability) paves way effective management high-altitude environments.

Language: Английский

Intranasal Administration of Acetaminophen-Loaded Poly(lactic-co-glycolic acid) Nanoparticles Increases Pain Threshold in Mice Rapidly Entering High Altitudes DOI Creative Commons
Qingqing Huang, Xingyue Han, Li Jin

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 341 - 341

Published: March 6, 2025

Background/Objectives: Orally or intravenously administered acetaminophen experiences considerable liver first-pass elimination and may cause liver/kidney damage. This work examined the pharmacological effects of acetaminophen-loaded poly(lactic-co-glycolic acid) nanoparticles (AAP PLGA NPs) intranasally to mice rapidly entering high altitudes. Methods: AAP NPs were prepared using ultrasonication-assisted emulsification solvent evaporation characterized in terms drug encapsulation efficiency loading, vitro vivo release behaviors, toxicity hippocampal neurons. In fluorescence imaging was used monitor concentrations (labeled with indocyanine green) brain blood after intranasal administration. The these on pain threshold altitudes evaluated through hot plate tail flick experiments. Results: found be noncytotoxic, highly biocompatible stable, a loading capacity 42.53% 3.87%, respectively. lasted for up 72 h, rate ~82%. After administration vivo, occurred slowly, mainly concentrated brain. Compared nonencapsulated acetaminophen, resulted higher levels delayed its elimination, thus increasing Conclusions: proposed strategy addresses common problems (low retention time bioavailability) paves way effective management high-altitude environments.

Language: Английский

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